Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15335
ชื่อเรื่อง: Dietary L-arginine normalizes endothelin-induced vascular contractions in cholesterol-fed rabbits
ผู้แต่ง: Phivthong-ngam L.
Bode-Böger S.M.
Böger R.H.
Böhme M.
Brandes R.P.
Mügge A.
Frölich J.C.
Keywords: arginine
endothelin 1
nitric oxide
animal experiment
animal tissue
article
atherosclerosis
blood vessel reactivity
cholesterol intake
controlled study
endothelium
hypercholesterolemia
nonhuman
priority journal
rabbit
urinary excretion
vasoconstriction
Animals
Arginine
Cholesterol
Cholesterol, Dietary
Creatine
Drug Interactions
Endothelin-1
Hypercholesterolemia
Male
Metabolic Clearance Rate
Nitrates
Rabbits
Vascular Resistance
Vasoconstriction
วันที่เผยแพร่: 1998
บทคัดย่อ: The endothelium regulates vascular function by releasing the vasodilator autacoid nitric oxide (NO) and the vasoconstrictor peptide endothelin-1 (ET- 1). Impaired activity of NO as well as excessive activity of ET-1 have been demonstrated in hypercholesterolemia and atherosclerosis. Because dietary L- arginine can restore NO function and improve abnormal endothelium-dependent relaxation in hypercholesterolemic rabbits, we examined the effects of dietary supplementation with L-arginine in cholesterol-fed rabbits on endothelium-dependent vascular relaxation and ET-1-induced vascular contraction, as well as the systemic synthesis of ET-1. Rabbits were initially fed a diet enriched with 1% cholesterol for 4 weeks, followed by 0.5% cholesterol alone or supplemented with 2% L-arginine in drinking water during the next 12 weeks. Cholesterol feeding impaired endothelium-dependent relaxation of rabbit aortic rings ex vivo and increased urinary immunoreactive ET-1 excretion, along with decreased urinary nitrate excretion, an index of NO production. L-Arginine partially restored endothelium-dependent relaxation in parallel to increased urinary nitrate excretion and decreased urinary immunoreactive ET-1 excretion. Selective inhibition of ET-A receptors with BQ123 partially restored endothelium- dependent relaxation in hypercholesterolemic rabbits but had no effect on arterial rings from rabbits supplemented with L-arginine or from control animals. The contractile vascular response of aortic rings to exogenous ET-1 was increased in rabbits fed a high-cholesterol diet; this enhanced contractility to ET-1 was completely reversed by L-arginine. These data suggest that L-arginine restores endothelial function and normalizes the synthesis and vasoconstrictor response to ET-1 in hypercholesterolemia.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15335
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0345487006&doi=10.1097%2f00005344-199808000-00019&partnerID=40&md5=ac5d532c94b498fe991062182c3b4b7e
ISSN: 1602446
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.