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dc.contributor.authorPhivthong-ngam L.
dc.contributor.authorBode-Böger S.M.
dc.contributor.authorBöger R.H.
dc.contributor.authorBöhme M.
dc.contributor.authorBrandes R.P.
dc.contributor.authorMügge A.
dc.contributor.authorFrölich J.C.
dc.date.accessioned2021-04-05T04:33:34Z-
dc.date.available2021-04-05T04:33:34Z-
dc.date.issued1998
dc.identifier.issn1602446
dc.identifier.other2-s2.0-0345487006
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/15335-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0345487006&doi=10.1097%2f00005344-199808000-00019&partnerID=40&md5=ac5d532c94b498fe991062182c3b4b7e
dc.description.abstractThe endothelium regulates vascular function by releasing the vasodilator autacoid nitric oxide (NO) and the vasoconstrictor peptide endothelin-1 (ET- 1). Impaired activity of NO as well as excessive activity of ET-1 have been demonstrated in hypercholesterolemia and atherosclerosis. Because dietary L- arginine can restore NO function and improve abnormal endothelium-dependent relaxation in hypercholesterolemic rabbits, we examined the effects of dietary supplementation with L-arginine in cholesterol-fed rabbits on endothelium-dependent vascular relaxation and ET-1-induced vascular contraction, as well as the systemic synthesis of ET-1. Rabbits were initially fed a diet enriched with 1% cholesterol for 4 weeks, followed by 0.5% cholesterol alone or supplemented with 2% L-arginine in drinking water during the next 12 weeks. Cholesterol feeding impaired endothelium-dependent relaxation of rabbit aortic rings ex vivo and increased urinary immunoreactive ET-1 excretion, along with decreased urinary nitrate excretion, an index of NO production. L-Arginine partially restored endothelium-dependent relaxation in parallel to increased urinary nitrate excretion and decreased urinary immunoreactive ET-1 excretion. Selective inhibition of ET-A receptors with BQ123 partially restored endothelium- dependent relaxation in hypercholesterolemic rabbits but had no effect on arterial rings from rabbits supplemented with L-arginine or from control animals. The contractile vascular response of aortic rings to exogenous ET-1 was increased in rabbits fed a high-cholesterol diet; this enhanced contractility to ET-1 was completely reversed by L-arginine. These data suggest that L-arginine restores endothelial function and normalizes the synthesis and vasoconstrictor response to ET-1 in hypercholesterolemia.
dc.subjectarginine
dc.subjectendothelin 1
dc.subjectnitric oxide
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectatherosclerosis
dc.subjectblood vessel reactivity
dc.subjectcholesterol intake
dc.subjectcontrolled study
dc.subjectendothelium
dc.subjecthypercholesterolemia
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrabbit
dc.subjecturinary excretion
dc.subjectvasoconstriction
dc.subjectAnimals
dc.subjectArginine
dc.subjectCholesterol
dc.subjectCholesterol, Dietary
dc.subjectCreatine
dc.subjectDrug Interactions
dc.subjectEndothelin-1
dc.subjectHypercholesterolemia
dc.subjectMale
dc.subjectMetabolic Clearance Rate
dc.subjectNitrates
dc.subjectRabbits
dc.subjectVascular Resistance
dc.subjectVasoconstriction
dc.titleDietary L-arginine normalizes endothelin-induced vascular contractions in cholesterol-fed rabbits
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Cardiovascular Pharmacology. Vol 32, No.2 (1998), p.300-307
dc.identifier.doi10.1097/00005344-199808000-00019
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