Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15176
Title: Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group
Authors: Samosorn S.
Tanwirat B.
Muhamad N.
Casadei G.
Tomkiewicz D.
Lewis K.
Suksamrarn A.
Prammananan T.
Gornall K.C.
Beck J.L.
Bremner J.B.
Keywords: 5 nitro 2 phenyl 1h indole
9,10 dimethoxy 13 [2 (5 nitro 1h indol 2 yl)benzyloxy] 5,6 dihydrobenzo[g] 1,3 benzodioxolo[5,6 a]quinolizinium bromide
berberine
berberine 5 nitro 2 phenyl 1h indole conjugate
inf 55
NorA pump inhibitor
protein inhibitor
unclassified drug
antibacterial activity
article
bacterial strain
controlled study
drug conjugation
drug potency
drug structure
drug synthesis
minimum inhibitory concentration
nonhuman
Staphylococcus aureus
Anti-Bacterial Agents
Bacterial Proteins
Berberine
Enterococcus faecalis
Ether, Ethyl
Indoles
Intercalating Agents
Molecular Structure
Multidrug Resistance-Associated Proteins
Staphylococcus aureus
Bacteria (microorganisms)
Staphylococcus aureus
Issue Date: 2009
Abstract: Conjugation of the NorA substrate berberine and the NorA inhibitor 5-nitro-2-phenyl-1H-indole via a methylene ether linking group gave the 13-substituted berberine-NorA inhibitor hybrid, 3. A series of simpler arylmethyl ether hybrid structures were also synthesized. The hybrid 3 showed excellent antibacterial activity (MIC Staphylococcus aureus, 1.7 μM), which was over 382-fold more active than the parent antibacterial berberine, against this bacterium. This compound was also shown to block the NorA efflux pump in S. aureus. © 2009 Elsevier Ltd.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15176
https://www.scopus.com/inward/record.uri?eid=2-s2.0-65549100031&doi=10.1016%2fj.bmc.2009.04.028&partnerID=40&md5=7d9a30a9bf253d6997e94fd82643d982
ISSN: 9680896
Appears in Collections:Scopus 1983-2021

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