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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15176
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dc.contributor.authorSamosorn S.
dc.contributor.authorTanwirat B.
dc.contributor.authorMuhamad N.
dc.contributor.authorCasadei G.
dc.contributor.authorTomkiewicz D.
dc.contributor.authorLewis K.
dc.contributor.authorSuksamrarn A.
dc.contributor.authorPrammananan T.
dc.contributor.authorGornall K.C.
dc.contributor.authorBeck J.L.
dc.contributor.authorBremner J.B.
dc.date.accessioned2021-04-05T04:32:50Z-
dc.date.available2021-04-05T04:32:50Z-
dc.date.issued2009
dc.identifier.issn9680896
dc.identifier.other2-s2.0-65549100031
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/15176-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-65549100031&doi=10.1016%2fj.bmc.2009.04.028&partnerID=40&md5=7d9a30a9bf253d6997e94fd82643d982
dc.description.abstractConjugation of the NorA substrate berberine and the NorA inhibitor 5-nitro-2-phenyl-1H-indole via a methylene ether linking group gave the 13-substituted berberine-NorA inhibitor hybrid, 3. A series of simpler arylmethyl ether hybrid structures were also synthesized. The hybrid 3 showed excellent antibacterial activity (MIC Staphylococcus aureus, 1.7 μM), which was over 382-fold more active than the parent antibacterial berberine, against this bacterium. This compound was also shown to block the NorA efflux pump in S. aureus. © 2009 Elsevier Ltd.
dc.subject5 nitro 2 phenyl 1h indole
dc.subject9,10 dimethoxy 13 [2 (5 nitro 1h indol 2 yl)benzyloxy] 5,6 dihydrobenzo[g] 1,3 benzodioxolo[5,6 a]quinolizinium bromide
dc.subjectberberine
dc.subjectberberine 5 nitro 2 phenyl 1h indole conjugate
dc.subjectinf 55
dc.subjectNorA pump inhibitor
dc.subjectprotein inhibitor
dc.subjectunclassified drug
dc.subjectantibacterial activity
dc.subjectarticle
dc.subjectbacterial strain
dc.subjectcontrolled study
dc.subjectdrug conjugation
dc.subjectdrug potency
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectStaphylococcus aureus
dc.subjectAnti-Bacterial Agents
dc.subjectBacterial Proteins
dc.subjectBerberine
dc.subjectEnterococcus faecalis
dc.subjectEther, Ethyl
dc.subjectIndoles
dc.subjectIntercalating Agents
dc.subjectMolecular Structure
dc.subjectMultidrug Resistance-Associated Proteins
dc.subjectStaphylococcus aureus
dc.subjectBacteria (microorganisms)
dc.subjectStaphylococcus aureus
dc.titleAntibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationBioorganic and Medicinal Chemistry. Vol 17, No.11 (2009), p.3866-3872
dc.identifier.doi10.1016/j.bmc.2009.04.028
Appears in Collections:Scopus 1983-2021

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