Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14967
ชื่อเรื่อง: Evaluation of dermal irritancy potential of Carboxymethyl-chitosan hydrogel and poly-(acrylic acid) chitin hydrogel.
ผู้แต่ง: Rattanatayarom W.
Wattanasirichaigoon S.
Keywords: acrylic acid derivative
biomaterial
carboxymethyl chitosan
carboxymethyl-chitosan
chitin
chitosan
drug derivative
unclassified drug
animal
article
bandage
chemically induced disorder
edema
erythema
hydrogel
male
materials testing
physiology
rat
skin
Sprague Dawley rat
wound healing
Acrylates
Animals
Bandages
Biocompatible Materials
Chitin
Chitosan
Edema
Erythema
Hydrogel
Male
Materials Testing
Rats
Rats, Sprague-Dawley
Skin
Wound Healing
วันที่เผยแพร่: 2007
บทคัดย่อ: OBJECTIVE: The wound dressing synthesized from carboxymethylchitosan hydrogel (CM) and chitin-(polyacrylic acid) hydrogel (PAA) were examined for their dermal irritation potential response using the Draize test. MATERIAL AND METHOD: Eighteen male Sprague-Dawley rats were divided into three groups (6 rats/each). Rats in group 1 were designed as control, group 2 were treated with CM, and group 3 were treated with PAA. The test materials diameter 1 x 1 cm were topically applied on the skin in group 2 and 3. Two skin sites (1 x 1 cm in size) were located at the back. One site was intact and the other was abraded in such a way the stratum corneum had no bleeding. RESULT: After 24 and 72 hours of wrappings, the materials were removed and the test sites were evaluated in terms of erythema and edema using adopted Draize scoring system. At the end of the experiment, all rats were anesthesized with intravenous thiopental sodium. Blood samples from descending aorta were collected for liver and kidney function test and all organs were weighed. The results of this experiment showed 1) no irritation of both materials in this animal model; 2) no material-related induced liver and kidney dysfunction and 3) organ weights had no significant difference between the groups. CONCLUSION: Both CM and PAA should be considered safe to use in the purpose of wound dressing in further clinical trials.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14967
https://www.scopus.com/inward/record.uri?eid=2-s2.0-36049023191&partnerID=40&md5=ea4a50a2e69960e74f862462d0b624f1
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.