Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13345
ชื่อเรื่อง: Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy
ผู้แต่ง: Hirunsai M.
Yimlamai T.
Suksamrarn A.
Keywords: ecdysterone
muscle protein
muscle RING finger 1 protein
ecdysterone
ubiquitinated protein
achilles tendon
adult
animal experiment
animal model
animal tissue
Article
body weight
controlled study
histology
male
muscle atrophy
muscle mass
muscle wet weight
nonhuman
plantaris muscle
protein degradation
protein expression
rat
skeletal muscle
soleus muscle
tenotomy
ubiquitination
Western blotting
animal
drug effects
metabolism
muscle atrophy
pathology
protein degradation
randomization
signal transduction
skeletal muscle
subcutaneous drug administration
Wistar rat
Animals
Blotting, Western
Ecdysterone
Injections, Subcutaneous
Male
Muscle, Skeletal
Muscular Atrophy
Proteolysis
Random Allocation
Rats, Wistar
Signal Transduction
Tenotomy
Ubiquitinated Proteins
Ubiquitination
วันที่เผยแพร่: 2016
บทคัดย่อ: Background/Aim: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. Materials and Methods: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E). The TEN+20E group was administered 20E via subcutaneous injection to the right thigh for 7 days after tenotomy. Results: 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle. Conclusion: 20E treatment alleviates skeletal muscle atrophy partially mediated by ubiquitinate pathway, dependent on the muscle phenotype. © 2016, International Institute of Anticancer Research. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/13345
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994246675&doi=10.21873%2finvivo.11007&partnerID=40&md5=6a1b5fcb0dcc58301598696d69588ae3
ISSN: 0258851X
Appears in Collections:Scopus 1983-2021

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