1. Srinakharinwirot University Institutional Repository
  2. Articles from Academic Databases : SCOPUS
  3. Scopus 1983-2021
Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/13345
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHirunsai M.
dc.contributor.authorYimlamai T.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T03:23:23Z-
dc.date.available2021-04-05T03:23:23Z-
dc.date.issued2016
dc.identifier.issn0258851X
dc.identifier.other2-s2.0-84994246675
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/13345-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994246675&doi=10.21873%2finvivo.11007&partnerID=40&md5=6a1b5fcb0dcc58301598696d69588ae3
dc.description.abstractBackground/Aim: 20-Hydroxyecdystone (20E) is an ecdysteroid hormone which controls molting and reproduction in arthropods. 20E also produces a variety of effects in vertebrates, including enhancing protein synthesis and skeletal muscle regeneration. The effect of 20E on disuse muscle atrophy has not been reported to date. This study examined the proteolytic regulation of 20E in tenotomized rat slow soleus and fast plantaris muscles. Materials and Methods: Male Wistar rats were randomly divided into three groups: sedentary control (CON), tenotomy without 20E treatment (TEN), and tenotomy with treatment of 5 mg/kg BW of 20E (TEN+20E). The TEN+20E group was administered 20E via subcutaneous injection to the right thigh for 7 days after tenotomy. Results: 20E treatment tended to attenuate disuse muscle atrophy and reduced ubiquitination only in soleus muscle. Conclusion: 20E treatment alleviates skeletal muscle atrophy partially mediated by ubiquitinate pathway, dependent on the muscle phenotype. © 2016, International Institute of Anticancer Research. All rights reserved.
dc.subjectecdysterone
dc.subjectmuscle protein
dc.subjectmuscle RING finger 1 protein
dc.subjectecdysterone
dc.subjectubiquitinated protein
dc.subjectachilles tendon
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjecthistology
dc.subjectmale
dc.subjectmuscle atrophy
dc.subjectmuscle mass
dc.subjectmuscle wet weight
dc.subjectnonhuman
dc.subjectplantaris muscle
dc.subjectprotein degradation
dc.subjectprotein expression
dc.subjectrat
dc.subjectskeletal muscle
dc.subjectsoleus muscle
dc.subjecttenotomy
dc.subjectubiquitination
dc.subjectWestern blotting
dc.subjectanimal
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectmuscle atrophy
dc.subjectpathology
dc.subjectprotein degradation
dc.subjectrandomization
dc.subjectsignal transduction
dc.subjectskeletal muscle
dc.subjectsubcutaneous drug administration
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectBlotting, Western
dc.subjectEcdysterone
dc.subjectInjections, Subcutaneous
dc.subjectMale
dc.subjectMuscle, Skeletal
dc.subjectMuscular Atrophy
dc.subjectProteolysis
dc.subjectRandom Allocation
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.subjectTenotomy
dc.subjectUbiquitinated Proteins
dc.subjectUbiquitination
dc.titleEffect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationIn Vivo. Vol 30, No.6 (2016), p.869-877
dc.identifier.doi10.21873/invivo.11007
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.