High prevalence of hyperuricemia and lack of association with rs2280205 and rs6820230 alleles of the slc2a9 gene in urban bangkok, thailand

Abstract

Genetic variants of SLC2A9 have been reported to be associated with deficiencies in the excretion of urate and with urate transporter gene 9 (GLUT9) activity. However, the evidence remains inconclusive and no information is available about SLC2A9 genetic variants (rs2280205 and rs6820230) association with hyperuricemia (HUA) in the Thai population. We decided to determine whether rs2280205 and rs6820230 alleles of the SLC2A9 gene are associated with HUA in a cross-sectional study that included 193 subjects in urban Bangkok, Thailand. These single-nucleotide polymorphisms were analyzed using unconditional logistic regression. The prevalence of HUA was 31.1%. Males (HUA defined as serum urate levels >7.0 mg/dL) had a higher prevalence of HUA than females (>6.0 mg/dL) (42.7 versus 24.8%). By SLC2A9 SNP association analysis, the rs2280205 and rs6820230 variants were not significantly associated with HUA (adjusted odds ratio (aOR) = 5.59, 95% CI = 0.50-62.95; aOR = 0.77, 95% CI = 0.11-5.45), respectively). The prevalence of HUA was much higher in this urban Thai population than in similar studies in rural areas of the country and also compared to the mean frequency in developed countries such as the USA (usually 10% or less). The haplotypes rs6820230 and rs2280205 did not influence the risk for HUA in these Bangkok subjects. We concluded that the prevalence of HUA is extremely high in urban Bangkok and that these SNPs are not associated with HUA in this population. © FUNPEC-RP.