Publication:
High prevalence of hyperuricemia and lack of association with rs2280205 and rs6820230 alleles of the slc2a9 gene in urban bangkok, thailand

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Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

16765680

DOI

10.4238/gmr18511

Other identifier(s)

2-s2.0-85083097340

Rights Holder(s)

Scopus

Bibliographic Citation

Genetics and Molecular Research. Vol 19, No.1 (2020)

Suggested Citation

Wannaiampikul S., Sangsawangchot P., Tanunyutthawongse C. High prevalence of hyperuricemia and lack of association with rs2280205 and rs6820230 alleles of the slc2a9 gene in urban bangkok, thailand. Genetics and Molecular Research. Vol 19, No.1 (2020). doi:10.4238/gmr18511 Retrieved from: https://hdl.handle.net/20.500.14740/4838

Title

High prevalence of hyperuricemia and lack of association with rs2280205 and rs6820230 alleles of the slc2a9 gene in urban bangkok, thailand

Author(s)

Wannaiampikul S.
 Sangsawangchot P.
 Tanunyutthawongse C.

Abstract

Genetic variants of SLC2A9 have been reported to be associated with deficiencies in the excretion of urate and with urate transporter gene 9 (GLUT9) activity. However, the evidence remains inconclusive and no information is available about SLC2A9 genetic variants (rs2280205 and rs6820230) association with hyperuricemia (HUA) in the Thai population. We decided to determine whether rs2280205 and rs6820230 alleles of the SLC2A9 gene are associated with HUA in a cross-sectional study that included 193 subjects in urban Bangkok, Thailand. These single-nucleotide polymorphisms were analyzed using unconditional logistic regression. The prevalence of HUA was 31.1%. Males (HUA defined as serum urate levels >7.0 mg/dL) had a higher prevalence of HUA than females (>6.0 mg/dL) (42.7 versus 24.8%). By SLC2A9 SNP association analysis, the rs2280205 and rs6820230 variants were not significantly associated with HUA (adjusted odds ratio (aOR) = 5.59, 95% CI = 0.50-62.95; aOR = 0.77, 95% CI = 0.11-5.45), respectively). The prevalence of HUA was much higher in this urban Thai population than in similar studies in rural areas of the country and also compared to the mean frequency in developed countries such as the USA (usually 10% or less). The haplotypes rs6820230 and rs2280205 did not influence the risk for HUA in these Bangkok subjects. We concluded that the prevalence of HUA is extremely high in urban Bangkok and that these SNPs are not associated with HUA in this population. © FUNPEC-RP.

Subject(s)

Cholesterol
 Glucose
 High density lipoprotein cholesterol
 Low density lipoprotein cholesterol
 Triacylglycerol
 Acute disease
 Adult
 Allele
 Article
 Cardiovascular disease
 Cholesterol blood level
 Controlled study
 Cross-sectional study
 Female
 Gene
 Genetic association
 Genetic risk
 Genetic variability
 Glucose blood level
 Haplotype
 Heart disease
 High density lipoprotein cholesterol level
 Human
 Hyperuricemia
 Kidney disease
 Kidney dysfunction
 Logistic regression analysis
 Low density lipoprotein cholesterol level
 Major clinical study
 Male
 Middle aged
 Prevalence
 Single nucleotide polymorphism
 SLC2A9 gene
 Thailand
 Triacylglycerol blood level
 United States
 Urban population
 Urban rural difference
 Uric acid blood level

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URI

https://hdl.handle.net/20.500.14740/4838

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Scopus: Year 1983-2021

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