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Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

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dc.contributor.authorPrachayasittikul S.
dc.contributor.authorManam P.
dc.contributor.authorChinworrungsee M.
dc.contributor.authorIsarankura-Na-Ayudhya C.
dc.contributor.authorRuchirawat S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T04:31:58Z
dc.date.available2021-04-05T04:31:58Z
dc.date.issued2009
dc.date.issuedBE2552
dc.description.abstractThis study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
dc.format.mimetypeapplication/pdf
dc.identifier.citationMolecules. Vol 14, No.11 (2009), p.4414-4424
dc.identifier.doi10.3390/molecules14114414
dc.identifier.issn14203049
dc.identifier.other2-s2.0-73349142009
dc.identifier.urihttps://hdl.handle.net/20.500.14740/3949
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherAlkaloid
dc.subject.otherAntiinfective agent
dc.subject.otherAntimalarial agent
dc.subject.otherFlavanone derivative
dc.subject.otherOnychine
dc.subject.otherPlant extract
dc.subject.otherPyridone derivative
dc.subject.otherSitosterol
dc.subject.otherSitosterol derivative
dc.subject.otherStigmasterol
dc.subject.otherTriterpene
dc.subject.otherArticle
dc.subject.otherCell line
dc.subject.otherCell survival
dc.subject.otherChemical structure
dc.subject.otherChemistry
dc.subject.otherDrug effect
dc.subject.otherHuman
dc.subject.otherMicrobiological examination
dc.subject.otherPlasmodium falciparum
dc.subject.otherPolyalthia
dc.subject.otherTumor cell line
dc.subject.otherAlkaloids
dc.subject.otherAnti-Infective Agents
dc.subject.otherAntimalarials
dc.subject.otherCell Line
dc.subject.otherCell Line, Tumor
dc.subject.otherCell Survival
dc.subject.otherFlavanones
dc.subject.otherHumans
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherMolecular Structure
dc.subject.otherPlant Extracts
dc.subject.otherPlasmodium falciparum
dc.subject.otherPolyalthia
dc.subject.otherPyridones
dc.subject.otherSitosterols
dc.subject.otherStigmasterol
dc.subject.otherTriterpenes
dc.titleBioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-73349142009&doi=10.3390%2fmolecules14114414&partnerID=40&md5=0dafd56146fb6c95cc791de3be2ea54c

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