Publication:
Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

2
0

Issued Date

2009

Resource Type

Article

File Type

application/pdf

ISSN

14203049

DOI

10.3390/molecules14114414

Other identifier(s)

2-s2.0-73349142009

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Molecules. Vol 14, No.11 (2009), p.4414-4424

Suggested Citation

Prachayasittikul S., Manam P., Chinworrungsee M., Isarankura-Na-Ayudhya C., Ruchirawat S., Prachayasittikul V. Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.. Molecules. Vol 14, No.11 (2009), p.4414-4424. doi:10.3390/molecules14114414 Retrieved from: https://hdl.handle.net/20.500.14740/3949

Title

Bioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.

Author(s)

Prachayasittikul S.
 Manam P.
 Chinworrungsee M.
 Isarankura-Na-Ayudhya C.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

Subject(s)

Alkaloid
 Antiinfective agent
 Antimalarial agent
 Flavanone derivative
 Onychine
 Plant extract
 Pyridone derivative
 Sitosterol
 Sitosterol derivative
 Stigmasterol
 Triterpene
 Article
 Cell line
 Cell survival
 Chemical structure
 Chemistry
 Drug effect
 Human
 Microbiological examination
 Plasmodium falciparum
 Polyalthia
 Tumor cell line
 Alkaloids
 Anti-Infective Agents
 Antimalarials
 Cell Line
 Cell Line, Tumor
 Cell Survival
 Flavanones
 Humans
 Microbial Sensitivity Tests
 Molecular Structure
 Plant Extracts
 Plasmodium falciparum
 Polyalthia
 Pyridones
 Sitosterols
 Stigmasterol
 Triterpenes

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URI

https://hdl.handle.net/20.500.14740/3949

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Scopus: Year 1983-2021

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