Publication:
Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

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dc.contributor.authorKaruwanarint P.
dc.contributor.authorPhonrat B.
dc.contributor.authorTungtrongchitr A.
dc.contributor.authorSuriyaprom K.
dc.contributor.authorChuengsamarn S.
dc.contributor.authorSchweigert F.J.
dc.contributor.authorTungtrongchitr R.
dc.date.accessioned2021-04-05T03:23:55Z
dc.date.available2021-04-05T03:23:55Z
dc.date.issued2018
dc.date.issuedBE2561
dc.description.abstractAim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-Type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais. © 2018 2018 Future Medicine Ltd.
dc.format.mimetypeapplication/pdf
dc.identifier.citationBiomarkers in Medicine. Vol 12, No.5 (2018), p.465-473
dc.identifier.doi10.2217/bmm-2018-0029
dc.identifier.issn17520363
dc.identifier.other2-s2.0-85046833886
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5451
dc.rights.holderScopus
dc.subject.otherGlobulin
dc.subject.otherGlucose
dc.subject.otherVitamin D binding protein
dc.subject.otherGlobulin
dc.subject.otherVitamin D binding protein
dc.subject.otherAdult
dc.subject.otherAge distribution
dc.subject.otherAged
dc.subject.otherArticle
dc.subject.otherControlled study
dc.subject.otherFemale
dc.subject.otherGenetic association
dc.subject.otherGenetic susceptibility
dc.subject.otherGenetic variation
dc.subject.otherGenotype
dc.subject.otherGlucose blood level
dc.subject.otherHeterozygote
dc.subject.otherHigh risk population
dc.subject.otherHuman
dc.subject.otherMajor clinical study
dc.subject.otherMale
dc.subject.otherMetabolic syndrome X
dc.subject.otherProtein analysis
dc.subject.otherProtein blood level
dc.subject.otherProtein polymorphism
dc.subject.otherRisk factor
dc.subject.otherSystolic blood pressure
dc.subject.otherThai (people)
dc.subject.otherWestern blotting
dc.subject.otherWild type
dc.subject.otherBlood
dc.subject.otherGenetic predisposition
dc.subject.otherGenetics
dc.subject.otherMetabolic syndrome X
dc.subject.otherMetabolism
dc.subject.otherMiddle aged
dc.subject.otherSingle nucleotide polymorphism
dc.subject.otherAdult
dc.subject.otherAged
dc.subject.otherFemale
dc.subject.otherGenetic Predisposition to Disease
dc.subject.otherGlobulins
dc.subject.otherHumans
dc.subject.otherMale
dc.subject.otherMetabolic Syndrome
dc.subject.otherMiddle Aged
dc.subject.otherPolymorphism, Single Nucleotide
dc.subject.otherVitamin D-Binding Protein
dc.titleVitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85046833886&doi=10.2217%2fbmm-2018-0029&partnerID=40&md5=0457478fa4a77ffbae253544f7ed5a4a

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