Publication:
Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

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Issued Date

2018

Resource Type

Article

File Type

application/pdf

ISSN

17520363

DOI

10.2217/bmm-2018-0029

Other identifier(s)

2-s2.0-85046833886

Rights Holder(s)

Scopus

Bibliographic Citation

Biomarkers in Medicine. Vol 12, No.5 (2018), p.465-473

Suggested Citation

Karuwanarint P., Phonrat B., Tungtrongchitr A., Suriyaprom K., Chuengsamarn S., Schweigert F.J., Tungtrongchitr R. Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome. Biomarkers in Medicine. Vol 12, No.5 (2018), p.465-473. doi:10.2217/bmm-2018-0029 Retrieved from: https://hdl.handle.net/20.500.14740/5451

Title

Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome

Author(s)

Karuwanarint P.
 Phonrat B.
 Tungtrongchitr A.
 Suriyaprom K.
 Chuengsamarn S.
 Schweigert F.J.
 Tungtrongchitr R.

Abstract

Aim: To investigate the relationship of Vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population. Materials & methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-Type (odds ratio: 3.25; p = 0.004). Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais. © 2018 2018 Future Medicine Ltd.

Subject(s)

Globulin
 Glucose
 Vitamin D binding protein
 Globulin
 Vitamin D binding protein
 Adult
 Age distribution
 Aged
 Article
 Controlled study
 Female
 Genetic association
 Genetic susceptibility
 Genetic variation
 Genotype
 Glucose blood level
 Heterozygote
 High risk population
 Human
 Major clinical study
 Male
 Metabolic syndrome X
 Protein analysis
 Protein blood level
 Protein polymorphism
 Risk factor
 Systolic blood pressure
 Thai (people)
 Western blotting
 Wild type
 Blood
 Genetic predisposition
 Genetics
 Metabolic syndrome X
 Metabolism
 Middle aged
 Single nucleotide polymorphism
 Adult
 Aged
 Female
 Genetic Predisposition to Disease
 Globulins
 Humans
 Male
 Metabolic Syndrome
 Middle Aged
 Polymorphism, Single Nucleotide
 Vitamin D-Binding Protein

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URI

https://hdl.handle.net/20.500.14740/5451

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Scopus: Year 1983-2021

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