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A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

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dc.contributor.authorGornall K.C.
dc.contributor.authorSamosorn S.
dc.contributor.authorTanwirat B.
dc.contributor.authorSuksamrarn A.
dc.contributor.authorBremner J.B.
dc.contributor.authorKelso M.J.
dc.contributor.authorBeck J.L.
dc.date.accessioned2021-04-05T03:36:24Z
dc.date.available2021-04-05T03:36:24Z
dc.date.issued2010
dc.date.issuedBE2553
dc.description.abstractESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.
dc.format.mimetypeapplication/pdf
dc.identifier.citationChemical Communications. Vol 46, No.35 (2010), p.6602-6604
dc.identifier.doi10.1039/c0cc01933j
dc.identifier.issn13597345
dc.identifier.other2-s2.0-77956046998
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7547
dc.rights.holderScopus
dc.subject.other2 naphthalenyl
dc.subject.other5 nitro 2 phenylindolyl
dc.subject.otherBerberine derivative
dc.subject.otherDaunorubicin
dc.subject.otherDouble stranded DNA
dc.subject.otherGuanine quadruplex
dc.subject.otherUnclassified drug
dc.subject.otherArticle
dc.subject.otherDNA binding
dc.subject.otherDNA sequence
dc.subject.otherDNA structure
dc.subject.otherElectrospray mass spectrometry
dc.subject.otherLigand binding
dc.subject.otherMolecule
dc.titleA mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77956046998&doi=10.1039%2fc0cc01933j&partnerID=40&md5=d896c3fd3d71430da27ee1792567e721

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