Publication:
A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

13597345

DOI

10.1039/c0cc01933j

Other identifier(s)

2-s2.0-77956046998

Rights Holder(s)

Scopus

Bibliographic Citation

Chemical Communications. Vol 46, No.35 (2010), p.6602-6604

Suggested Citation

Gornall K.C., Samosorn S., Tanwirat B., Suksamrarn A., Bremner J.B., Kelso M.J., Beck J.L. A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. Chemical Communications. Vol 46, No.35 (2010), p.6602-6604. doi:10.1039/c0cc01933j Retrieved from: https://hdl.handle.net/20.500.14740/7547

Title

A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives

Author(s)

Gornall K.C.
 Samosorn S.
 Tanwirat B.
 Suksamrarn A.
 Bremner J.B.
 Kelso M.J.
 Beck J.L.

Abstract

ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.

Subject(s)

2 naphthalenyl
 5 nitro 2 phenylindolyl
 Berberine derivative
 Daunorubicin
 Double stranded DNA
 Guanine quadruplex
 Unclassified drug
 Article
 DNA binding
 DNA sequence
 DNA structure
 Electrospray mass spectrometry
 Ligand binding
 Molecule

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URI

https://hdl.handle.net/20.500.14740/7547

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Scopus: Year 1983-2021

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