Publication:
Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities

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dc.contributor.authorPingaew R.
dc.contributor.authorWorachartcheewan A.
dc.contributor.authorPrachayasittikul V.
dc.contributor.authorPrachayasittikul S.
dc.contributor.authorRuchirawat S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T03:32:46Z
dc.date.available2021-04-05T03:32:46Z
dc.date.issued2013
dc.date.issuedBE2556
dc.description.abstractMetal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.
dc.format.mimetypeapplication/pdf
dc.identifier.citationLetters in Drug Design and Discovery. Vol 10, No.9 (2013), p.859-864
dc.identifier.doi10.2174/15701808113109990004
dc.identifier.issn15701808
dc.identifier.other2-s2.0-84887864374
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6523
dc.rights.holderScopus
dc.subject.other8 aminoquinoline derivative
dc.subject.otherCopper complex
dc.subject.otherDoxorubicin
dc.subject.otherEtoposide
dc.subject.otherLigand
dc.subject.otherManganese derivative
dc.subject.otherMetal complex
dc.subject.otherNickel complex
dc.subject.otherReactive nitrogen species
dc.subject.otherReactive oxygen metabolite
dc.subject.otherSuperoxide
dc.subject.otherSuperoxide dismutase
dc.subject.otherTransition element
dc.subject.otherUracil derivative
dc.subject.otherAntioxidant activity
dc.subject.otherArticle
dc.subject.otherCancer cell culture
dc.subject.otherComplex formation
dc.subject.otherControlled study
dc.subject.otherDrug cytotoxicity
dc.subject.otherDrug synthesis
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIC 50
dc.subject.otherInfrared spectroscopy
dc.subject.otherPriority journal
dc.subject.otherStructure activity relation
dc.subject.otherX ray powder diffraction
dc.titleTransition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84887864374&doi=10.2174%2f15701808113109990004&partnerID=40&md5=a3eee064f49f651dd797425acaef207d

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