Publication:
Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

15701808

DOI

10.2174/15701808113109990004

Other identifier(s)

2-s2.0-84887864374

Rights Holder(s)

Scopus

Bibliographic Citation

Letters in Drug Design and Discovery. Vol 10, No.9 (2013), p.859-864

Suggested Citation

Pingaew R., Worachartcheewan A., Prachayasittikul V., Prachayasittikul S., Ruchirawat S., Prachayasittikul V. Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities. Letters in Drug Design and Discovery. Vol 10, No.9 (2013), p.859-864. doi:10.2174/15701808113109990004 Retrieved from: https://hdl.handle.net/20.500.14740/6523

Title

Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities

Author(s)

Pingaew R.
 Worachartcheewan A.
 Prachayasittikul V.
 Prachayasittikul S.
 Ruchirawat S.
 Prachayasittikul V.

Abstract

Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.

Subject(s)

8 aminoquinoline derivative
 Copper complex
 Doxorubicin
 Etoposide
 Ligand
 Manganese derivative
 Metal complex
 Nickel complex
 Reactive nitrogen species
 Reactive oxygen metabolite
 Superoxide
 Superoxide dismutase
 Transition element
 Uracil derivative
 Antioxidant activity
 Article
 Cancer cell culture
 Complex formation
 Controlled study
 Drug cytotoxicity
 Drug synthesis
 Human
 Human cell
 IC 50
 Infrared spectroscopy
 Priority journal
 Structure activity relation
 X ray powder diffraction

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URI

https://hdl.handle.net/20.500.14740/6523

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Scopus: Year 1983-2021

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