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Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus

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dc.contributor.authorPatjana T.
dc.contributor.authorJantaharn P.
dc.contributor.authorKatrun P.
dc.contributor.authorMongkolthanaruk W.
dc.contributor.authorSuwannasai N.
dc.contributor.authorSenawong T.
dc.contributor.authorTontapha S.
dc.contributor.authorAmornkitbumrung V.
dc.contributor.authorMccloskey S.
dc.date.accessioned2022-03-10T13:17:26Z
dc.date.available2022-03-10T13:17:26Z
dc.date.issued2021
dc.date.issuedBE2564
dc.description.abstractThe ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Research. Vol 35, No.12 (2021), p.2010-2019
dc.identifier.doi10.1080/14786419.2019.1652292
dc.identifier.issn14786419
dc.identifier.other2-s2.0-85071024282
dc.identifier.urihttps://hdl.handle.net/20.500.14740/8130
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.other3,4 dihydro 5,7,8 trihydroxy 3 methylisocoumarin
dc.subject.other3,4 dihydro 8 hydroxy 7 methoxy 3 methylisocoumarin
dc.subject.other6 ethyl 7,8 dihydroxy 4h chromen 4 one
dc.subject.other6 ethyl 8 hydroxy 4h chromen 4 one
dc.subject.otherAntiinflammatory agent
dc.subject.otherCytotoxic agent
dc.subject.otherDiclofenac
dc.subject.otherNitric oxide
dc.subject.otherUnclassified drug
dc.subject.otherAntiinflammatory agent
dc.subject.otherAntineoplastic agent
dc.subject.otherBiological product
dc.subject.otherLipopolysaccharide
dc.subject.otherAntiinflammatory activity
dc.subject.otherArticle
dc.subject.otherCancer cell
dc.subject.otherCarbon nuclear magnetic resonance
dc.subject.otherCell viability
dc.subject.otherChemical structure
dc.subject.otherChemoprophylaxis
dc.subject.otherControlled study
dc.subject.otherCytotoxicity
dc.subject.otherFungus
dc.subject.otherIC50
dc.subject.otherInfrared spectroscopy
dc.subject.otherMacrophage
dc.subject.otherMass spectrometry
dc.subject.otherMTT assay
dc.subject.otherNonhuman
dc.subject.otherNuclear magnetic resonance
dc.subject.otherXylariales
dc.subject.otherAnimal
dc.subject.otherChemistry
dc.subject.otherHCT 116 cell line
dc.subject.otherHT-29 cell line
dc.subject.otherHuman
dc.subject.otherMetabolism
dc.subject.otherMouse
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherPreclinical study
dc.subject.otherRAW 264.7 cell line
dc.subject.otherAnimals
dc.subject.otherAnti-Inflammatory Agents
dc.subject.otherAntineoplastic Agents
dc.subject.otherBiological Products
dc.subject.otherDrug Evaluation, Preclinical
dc.subject.otherHCT116 Cells
dc.subject.otherHT29 Cells
dc.subject.otherHumans
dc.subject.otherLipopolysaccharides
dc.subject.otherMagnetic Resonance Spectroscopy
dc.subject.otherMice
dc.subject.otherMolecular Structure
dc.subject.otherNitric Oxide
dc.subject.otherRAW 264.7 Cells
dc.subject.otherXylariales
dc.titleAnti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
dc.typeArticle
dspace.entity.typePublication
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