Publication: Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
4
0
Issued Date
2021
Resource Type
File Type
application/pdf
ISSN
14786419
Other identifier(s)
2-s2.0-85071024282
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Natural Product Research. Vol 35, No.12 (2021), p.2010-2019
Suggested Citation
Patjana T., Jantaharn P., Katrun P., Mongkolthanaruk W., Suwannasai N., Senawong T., Tontapha S., Amornkitbumrung V., Mccloskey S. Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus. Natural Product Research. Vol 35, No.12 (2021), p.2010-2019. doi:10.1080/14786419.2019.1652292 Retrieved from: https://hdl.handle.net/20.500.14740/8130
Abstract
The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Subject(s)
3,4 dihydro 5,7,8 trihydroxy 3 methylisocoumarin
3,4 dihydro 8 hydroxy 7 methoxy 3 methylisocoumarin
6 ethyl 7,8 dihydroxy 4h chromen 4 one
6 ethyl 8 hydroxy 4h chromen 4 one
Antiinflammatory agent
Cytotoxic agent
Diclofenac
Nitric oxide
Unclassified drug
Antiinflammatory agent
Antineoplastic agent
Biological product
Lipopolysaccharide
Antiinflammatory activity
Article
Cancer cell
Carbon nuclear magnetic resonance
Cell viability
Chemical structure
Chemoprophylaxis
Controlled study
Cytotoxicity
Fungus
IC50
Infrared spectroscopy
Macrophage
Mass spectrometry
MTT assay
Nonhuman
Nuclear magnetic resonance
Xylariales
Animal
Chemistry
HCT 116 cell line
HT-29 cell line
Human
Metabolism
Mouse
Nuclear magnetic resonance spectroscopy
Preclinical study
RAW 264.7 cell line
Animals
Anti-Inflammatory Agents
Antineoplastic Agents
Biological Products
Drug Evaluation, Preclinical
HCT116 Cells
HT29 Cells
Humans
Lipopolysaccharides
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide
RAW 264.7 Cells
Xylariales
3,4 dihydro 8 hydroxy 7 methoxy 3 methylisocoumarin
6 ethyl 7,8 dihydroxy 4h chromen 4 one
6 ethyl 8 hydroxy 4h chromen 4 one
Antiinflammatory agent
Cytotoxic agent
Diclofenac
Nitric oxide
Unclassified drug
Antiinflammatory agent
Antineoplastic agent
Biological product
Lipopolysaccharide
Antiinflammatory activity
Article
Cancer cell
Carbon nuclear magnetic resonance
Cell viability
Chemical structure
Chemoprophylaxis
Controlled study
Cytotoxicity
Fungus
IC50
Infrared spectroscopy
Macrophage
Mass spectrometry
MTT assay
Nonhuman
Nuclear magnetic resonance
Xylariales
Animal
Chemistry
HCT 116 cell line
HT-29 cell line
Human
Metabolism
Mouse
Nuclear magnetic resonance spectroscopy
Preclinical study
RAW 264.7 cell line
Animals
Anti-Inflammatory Agents
Antineoplastic Agents
Biological Products
Drug Evaluation, Preclinical
HCT116 Cells
HT29 Cells
Humans
Lipopolysaccharides
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide
RAW 264.7 Cells
Xylariales