Publication:
α-Mangostin: Anti-inflammatory activity and metabolism by human cells

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

218561

DOI

10.1021/jf4004434

Other identifier(s)

2-s2.0-84876701750

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of Agricultural and Food Chemistry. Vol 61, No.16 (2013), p.3891-3900

Suggested Citation

Gutierrez-Orozco F., Chitchumroonchokchai C., Lesinski G.B., Suksamrarn S., Failla M.L. α-Mangostin: Anti-inflammatory activity and metabolism by human cells. Journal of Agricultural and Food Chemistry. Vol 61, No.16 (2013), p.3891-3900. doi:10.1021/jf4004434 Retrieved from: https://hdl.handle.net/20.500.14740/6673

Title

α-Mangostin: Anti-inflammatory activity and metabolism by human cells

Author(s)

Gutierrez-Orozco F.
 Chitchumroonchokchai C.
 Lesinski G.B.
 Suksamrarn S.
 Failla M.L.

Abstract

Information about the anti-inflammatory activity and metabolism of α-mangostin (α-MG), the most abundant xanthone in mangosteen fruit, in human cells is limited. On the basis of available literature, we hypothesized that α-MG will inhibit the secretion of pro-inflammatory mediators by control and activated macrophage-like THP-1, hepatic HepG2, enterocyte-like Caco-2, and colon HT-29 human cell lines, as well as primary human monocyte-derived macrophages (MDM), and that such activity would be influenced by the extent of metabolism of the xanthone. α-MG attenuated TNF-α and IL-8 secretion by the various cell lines but increased TNF-α output by both quiescent and LPS-treated MDM. The relative amounts of free and phase II metabolites of α-MG and other xanthones present in media 24 h after addition of α-MG was shown to vary by cell type and inflammatory insult. Increased transport of xanthones and their metabolites across Caco-2 cell monolayers suggests enhanced absorption during an inflammatory episode. The anti-inflammatory activities of xanthones and their metabolites in different tissues merit consideration. © 2013 American Chemical Society.

Subject(s)

Anti-inflammatory activity
 Enhanced absorption
 Human cell lines
 Human cells
 Human monocyte-derived macrophages
 Inflammation
 Mangosteen
 Xanthones
 Biomolecules
 Cell culture
 Macrophages
 Metabolism
 Metabolites
 Monolayers
 Tissue
 Physiology
 Garcinia mangostana
 Dyes, reagents, indicators, markers and buffers
 Mangostin
 Nonsteroid antiinflammatory agent
 Protein kinase inhibitor
 Xanthone derivative
 Cell line
 Cell survival
 Chemistry
 Drug effects
 Garcinia mangostana
 Human
 Inflammation
 Metabolism
 Anti-Inflammatory Agents, Non-Steroidal
 Cell Line
 Cell Survival
 Garcinia mangostana
 Humans
 Indicators and Reagents
 Inflammation
 Protein Kinase Inhibitors
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/6673

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Scopus: Year 1983-2021

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