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Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana

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dc.contributor.authorSuksamrarn S.
dc.contributor.authorSuwannapoch N.
dc.contributor.authorPhakhodee W.
dc.contributor.authorThanuhiranlert J.
dc.contributor.authorRatananukul P.
dc.contributor.authorChimnoi N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:56Z
dc.date.available2021-04-05T04:32:56Z
dc.date.issued2003
dc.date.issuedBE2546
dc.description.abstractPrenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C 5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds. © 2003 Pharmaceutical Society of Japan.
dc.format.mimetypeapplication/pdf
dc.identifier.citationChemical and Pharmaceutical Bulletin. Vol 51, No.7 (2003), p.857-859
dc.identifier.doi10.1248/cpb.51.857
dc.identifier.issn92363
dc.identifier.other2-s2.0-1542785862
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6614
dc.rights.holderScopus
dc.subject.otherAlpha mangostin
dc.subject.otherAntimycobacterial agent
dc.subject.otherGarcinia mangostana extract
dc.subject.otherGarcinone B
dc.subject.otherMangostin
dc.subject.otherPlant extract
dc.subject.otherTuberculostatic agent
dc.subject.otherUnclassified drug
dc.subject.otherXanthone derivative
dc.subject.otherAntiinfective agent
dc.subject.otherXanthone derivative
dc.subject.otherAntibacterial activity
dc.subject.otherArticle
dc.subject.otherDose response
dc.subject.otherDrug activity
dc.subject.otherDrug effect
dc.subject.otherDrug isolation
dc.subject.otherDrug screening
dc.subject.otherDrug structure
dc.subject.otherFruit
dc.subject.otherGarcinia mangostana
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMycobacterium
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherNonhuman
dc.subject.otherOxygenation
dc.subject.otherPlant seed
dc.subject.otherPrenylation
dc.subject.otherChemistry
dc.subject.otherFruit
dc.subject.otherGarcinia mangostana
dc.subject.otherIsolation and purification
dc.subject.otherMicrobiological examination
dc.subject.otherProtein processing
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherFruit
dc.subject.otherGarcinia mangostana
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherProtein Isoprenylation
dc.subject.otherXanthones
dc.titleAntimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-1542785862&doi=10.1248%2fcpb.51.857&partnerID=40&md5=1836b88c8e26226133b204b8a5a60261

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