Publication:
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana

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Issued Date

2003

Resource Type

Article

File Type

application/pdf

ISSN

92363

DOI

10.1248/cpb.51.857

Other identifier(s)

2-s2.0-1542785862

Rights Holder(s)

Scopus

Bibliographic Citation

Chemical and Pharmaceutical Bulletin. Vol 51, No.7 (2003), p.857-859

Suggested Citation

Suksamrarn S., Suwannapoch N., Phakhodee W., Thanuhiranlert J., Ratananukul P., Chimnoi N., Suksamrarn A. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chemical and Pharmaceutical Bulletin. Vol 51, No.7 (2003), p.857-859. doi:10.1248/cpb.51.857 Retrieved from: https://hdl.handle.net/20.500.14740/6614

Title

Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana

Author(s)

Suksamrarn S.
 Suwannapoch N.
 Phakhodee W.
 Thanuhiranlert J.
 Ratananukul P.
 Chimnoi N.
 Suksamrarn A.

Abstract

Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C 5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds. © 2003 Pharmaceutical Society of Japan.

Subject(s)

Alpha mangostin
 Antimycobacterial agent
 Garcinia mangostana extract
 Garcinone B
 Mangostin
 Plant extract
 Tuberculostatic agent
 Unclassified drug
 Xanthone derivative
 Antiinfective agent
 Xanthone derivative
 Antibacterial activity
 Article
 Dose response
 Drug activity
 Drug effect
 Drug isolation
 Drug screening
 Drug structure
 Fruit
 Garcinia mangostana
 Minimum inhibitory concentration
 Mycobacterium
 Mycobacterium tuberculosis
 Nonhuman
 Oxygenation
 Plant seed
 Prenylation
 Chemistry
 Fruit
 Garcinia mangostana
 Isolation and purification
 Microbiological examination
 Protein processing
 Anti-Bacterial Agents
 Fruit
 Garcinia mangostana
 Microbial Sensitivity Tests
 Protein Isoprenylation
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/6614

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Scopus: Year 1983-2021

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