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Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells

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dc.contributor.authorKritsanawong S.
dc.contributor.authorInnajak S.
dc.contributor.authorImoto M.
dc.contributor.authorWatanapokasin R.
dc.date.accessioned2021-04-05T03:23:54Z
dc.date.available2021-04-05T03:23:54Z
dc.date.issued2016
dc.date.issuedBE2559
dc.description.abstractα-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as 'queen of fruits'. The anticancer activity of α-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) and mitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that α-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ERα, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that α-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.
dc.format.mimetypeapplication/pdf
dc.identifier.citationInternational Journal of Oncology. Vol 48, No.5 (2016), p.2155-2165
dc.identifier.doi10.3892/ijo.2016.3399
dc.identifier.issn10196439
dc.identifier.other2-s2.0-84962623421
dc.identifier.urihttps://hdl.handle.net/20.500.14740/5440
dc.rights.holderScopus
dc.subject.otherAlpha mangostin
dc.subject.otherAntineoplastic agent
dc.subject.otherCaspase 3
dc.subject.otherCaspase 9
dc.subject.otherCytochrome c
dc.subject.otherDNA
dc.subject.otherEpidermal growth factor receptor 2
dc.subject.otherEstrogen receptor alpha
dc.subject.otherMitogen activated protein kinase 1
dc.subject.otherMitogen activated protein kinase 3
dc.subject.otherMitogen activated protein kinase p38
dc.subject.otherPhosphatidylinositol 3 kinase
dc.subject.otherPlant extract
dc.subject.otherProtein bcl 2
dc.subject.otherProtein kinase B
dc.subject.otherProtein mcl 1
dc.subject.otherRaf protein
dc.subject.otherStress activated protein kinase 1
dc.subject.otherUnclassified drug
dc.subject.otherAntineoplastic agent
dc.subject.otherEpidermal growth factor receptor 2
dc.subject.otherERBB2 protein, human
dc.subject.otherMangostin
dc.subject.otherXanthone derivative
dc.subject.otherAntiproliferative activity
dc.subject.otherApoptosis
dc.subject.otherArticle
dc.subject.otherBreast cancer cell line
dc.subject.otherCell cycle
dc.subject.otherCell nucleus
dc.subject.otherCell proliferation
dc.subject.otherCell viability
dc.subject.otherColony formation
dc.subject.otherControlled study
dc.subject.otherDNA fragmentation
dc.subject.otherDown regulation
dc.subject.otherDrug isolation
dc.subject.otherDrug mechanism
dc.subject.otherDrug structure
dc.subject.otherEnzyme release
dc.subject.otherFruit
dc.subject.otherGarcinia mangostana
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIC50
dc.subject.otherMitochondrial membrane potential
dc.subject.otherPriority journal
dc.subject.otherProtein cleavage
dc.subject.otherProtein expression
dc.subject.otherProtein phosphorylation
dc.subject.otherSignal transduction
dc.subject.otherT47D cell line
dc.subject.otherWestern blotting
dc.subject.otherApoptosis
dc.subject.otherBreast Neoplasms
dc.subject.otherCell survival
dc.subject.otherDrug effects
dc.subject.otherFemale
dc.subject.otherGene expression regulation
dc.subject.otherMetabolism
dc.subject.otherPhosphorylation
dc.subject.otherTumor cell line
dc.subject.otherAntineoplastic Agents
dc.subject.otherApoptosis
dc.subject.otherBreast Neoplasms
dc.subject.otherCell Line, Tumor
dc.subject.otherCell Proliferation
dc.subject.otherCell Survival
dc.subject.otherDNA Fragmentation
dc.subject.otherFemale
dc.subject.otherGene Expression Regulation, Neoplastic
dc.subject.otherHumans
dc.subject.otherMAP Kinase Signaling System
dc.subject.otherMembrane Potential, Mitochondrial
dc.subject.otherPhosphorylation
dc.subject.otherReceptor, ErbB-2
dc.subject.otherXanthones
dc.titleAntiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84962623421&doi=10.3892%2fijo.2016.3399&partnerID=40&md5=078d7c13cd4eba425924c821b30a40e7

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