Publication:
Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells

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Issued Date

2016

Resource Type

Article

File Type

application/pdf

ISSN

10196439

DOI

10.3892/ijo.2016.3399

Other identifier(s)

2-s2.0-84962623421

Rights Holder(s)

Scopus

Bibliographic Citation

International Journal of Oncology. Vol 48, No.5 (2016), p.2155-2165

Suggested Citation

Kritsanawong S., Innajak S., Imoto M., Watanapokasin R. Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. International Journal of Oncology. Vol 48, No.5 (2016), p.2155-2165. doi:10.3892/ijo.2016.3399 Retrieved from: https://hdl.handle.net/20.500.14740/5440

Title

Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells

Author(s)

Kritsanawong S.
 Innajak S.
 Imoto M.
 Watanapokasin R.

Abstract

α-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as 'queen of fruits'. The anticancer activity of α-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) and mitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that α-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ERα, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that α-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.

Subject(s)

Alpha mangostin
 Antineoplastic agent
 Caspase 3
 Caspase 9
 Cytochrome c
 DNA
 Epidermal growth factor receptor 2
 Estrogen receptor alpha
 Mitogen activated protein kinase 1
 Mitogen activated protein kinase 3
 Mitogen activated protein kinase p38
 Phosphatidylinositol 3 kinase
 Plant extract
 Protein bcl 2
 Protein kinase B
 Protein mcl 1
 Raf protein
 Stress activated protein kinase 1
 Unclassified drug
 Antineoplastic agent
 Epidermal growth factor receptor 2
 ERBB2 protein, human
 Mangostin
 Xanthone derivative
 Antiproliferative activity
 Apoptosis
 Article
 Breast cancer cell line
 Cell cycle
 Cell nucleus
 Cell proliferation
 Cell viability
 Colony formation
 Controlled study
 DNA fragmentation
 Down regulation
 Drug isolation
 Drug mechanism
 Drug structure
 Enzyme release
 Fruit
 Garcinia mangostana
 Human
 Human cell
 IC50
 Mitochondrial membrane potential
 Priority journal
 Protein cleavage
 Protein expression
 Protein phosphorylation
 Signal transduction
 T47D cell line
 Western blotting
 Apoptosis
 Breast Neoplasms
 Cell survival
 Drug effects
 Female
 Gene expression regulation
 Metabolism
 Phosphorylation
 Tumor cell line
 Antineoplastic Agents
 Apoptosis
 Breast Neoplasms
 Cell Line, Tumor
 Cell Proliferation
 Cell Survival
 DNA Fragmentation
 Female
 Gene Expression Regulation, Neoplastic
 Humans
 MAP Kinase Signaling System
 Membrane Potential, Mitochondrial
 Phosphorylation
 Receptor, ErbB-2
 Xanthones

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URI

https://hdl.handle.net/20.500.14740/5440

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Scopus: Year 1983-2021

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