Publication: A novel and easy-to-construct polymeric L-glutamic acid-modified sensor for urinary 1-hydroxypyrene detection: Human biomonitoring of polycyclic aromatic hydrocarbons exposure
2
0
Issued Date
2023
Resource Type
File Type
application/pdf
Rights Holder(s)
Scopus
Bibliographic Citation
Talanta. Vol 253, No. (2023)
Suggested Citation
Thangphatthanarungruang J., Chotsuwan C., Siangproh W. A novel and easy-to-construct polymeric L-glutamic acid-modified sensor for urinary 1-hydroxypyrene detection: Human biomonitoring of polycyclic aromatic hydrocarbons exposure. Talanta. Vol 253, No. (2023). doi:10.1016/j.talanta.2022.123929 Retrieved from: https://hdl.handle.net/20.500.14740/12523
Other Contributor(s)
Abstract
1-Hydroxypyrene (1-OHP), a metabolite of polycyclic aromatic hydrocarbons (PAHs), is a frequently used biomarker for assessing human exposure to PAHs. Therefore, the technology that provides a quick, simple, cost-effective, portable, accurate, precise, and reliable test is still in great demand. To the best of our knowledge, the creation of an electrochemical device based on poly(L-glutamic acid)-modified a screen-printed graphene electrode (poly(L-GA)/SPGE) for 1-OHP detection was described for the first time. The developed sensor was simply and rapidly manufactured via only a single step of electropolymerization. All the concerned parameters and electroanalytical conditions were studied to obtain the best performance of the methodology. Under optimal conditions, the 1-OHP sensing provided a linear range of 1–1000 nM with the limits of detection and quantification of 0.95 and 3.16 nM, respectively. Moreover, this developed sensor was successfully utilized by determining 1-OHP in human urine samples. In comparison with conventional methods, this newly proposed electrochemical methodology might be tremendously valuable for 1-OHP evaluation in environmental and occupational applications, leading to the early detection of illness risk linked to PAHs in the human body. © 2022 Elsevier B.V.