Publication:
Correlation of low levels of serum carotenoids with increased risk of cardiovascular diseases

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Issued Date

2010

Resource Type

Article

File Type

application/pdf

ISSN

9702067

Other identifier(s)

2-s2.0-79955678189

Rights Holder(s)

Scopus

Bibliographic Citation

Biomedicine. Vol 30, No.4 (2010), p.436-443

Suggested Citation

Rerksuppaphol S., Chansiri K., Rerksuppaphol L., Loetthiraphan S., Chansiri G. Correlation of low levels of serum carotenoids with increased risk of cardiovascular diseases. Biomedicine. Vol 30, No.4 (2010), p.436-443. Retrieved from: https://hdl.handle.net/20.500.14740/7536

Title

Correlation of low levels of serum carotenoids with increased risk of cardiovascular diseases

Author(s)

Rerksuppaphol S.
 Chansiri K.
 Rerksuppaphol L.
 Loetthiraphan S.
 Chansiri G.

Abstract

Background & Objective: Cardiovascular disease (CVD) is one of major cause of morbidity and mortality worldwide. Evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the cardiovascular disease risk. Few data are reported concerning oriental population. Objective of this study is to investigate the serum antioxidant levels in cardiovascular disease patients in comparison to healthy controls in Thai population. Methods: Forty CVD patients and forty self-reported healthy volunteers were enrolled in the study. Serum carotenoids levels, including lutein, zeaxanthin, β-cryptoxanthin, lycopene, α and β-carotene, and retinol and tocopherols (alpha-and delta-) levels were quantified with HPLC procedure. Superoxide dismutase (SOD) and catalase activity was evaluated through an enzymatic assay. Results: Lutein, zeaxanthin, and beta-cryptoxanthin in CVD patients were significantly lower than in controls (0.84 versus 1.79 ng/ml, 3.08 versus 5.48 ng/ml, and 3.01 versus 5.20 ng/ml, respectively; p <0.05), while SOD and catalase activity was significantly higher in CVD patients than in controls (91.75 versus 63.63 ng/ml and 2.76 versus 2.09 nmol/min/ ml, respectively; p <0.05). Interpretation & Conclusion: These data reveal that CVD patients have lower levels of some non-enzymatic antioxidants but have higher enzymatic antioxidants than those in the healthy controls.

Subject(s)

Alpha carotene
 Alpha tocopherol
 Beta carotene
 Beta cryptoxanthin
 Carotenoid
 Catalase
 Delta tocopherol
 Lycopene
 Retinol
 Superoxide dismutase
 Xanthophyll
 Zeaxanthin
 Adult
 Aged
 Alpha carotene blood level
 Alpha tocopherol blood level
 Article
 Beta carotene blood level
 Beta cryptoxanthin blood level
 Cardiovascular disease
 Cardiovascular risk
 Carotenoid blood level
 Controlled study
 Delta tocopherol blood level
 Enzyme activity
 Female
 High performance liquid chromatography
 Human
 Lycopene blood level
 Major clinical study
 Male
 Retinol blood level
 Self report
 Thailand
 Vitamin blood level
 Xanthophyll blood level
 Zeaxanthin blood level

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URI

https://hdl.handle.net/20.500.14740/7536

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Scopus: Year 1983-2021

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