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A new cerebroside and the cytotoxic constituents isolated from Xylaria allantoidea SWUF76

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dc.contributor.authorMccloskey S.
dc.contributor.authorNoppawan S.
dc.contributor.authorMongkolthanaruk W.
dc.contributor.authorSuwannasai N.
dc.contributor.authorSenawong T.
dc.contributor.authorPrawat U.
dc.date.accessioned2021-04-05T03:23:10Z
dc.date.available2021-04-05T03:23:10Z
dc.date.issued2017
dc.date.issuedBE2560
dc.description.abstractA new cerebroside, namely allantoside (1), and 10 known compounds (2–11) were isolated from Xylaria allantoidea SWUF76. The structure of compound 1 was determined by comprehensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance (NMR) as well as high-resolution electron ionisation mass spectrometry (HREIMS) and electrospray ionisation mass spectrometry (ESIMS). Compounds 1, 4, 5, 6, 7, 8 and 11 were evaluated for cytotoxic activities against cancer cell lines (Hela, HT29, HCT116 and MCF-7) and normal Vero cell lines by MTT assay. Compounds 6 and 7 exhibited anticancer activity after 24 h of treatment. Compound 7 showed significant cytotoxicity against Hela (IC50 = 2.24 μg/mL), HT29 (IC50 = 2.51 μg/mL), HCT116 (IC50 = 3.50 μg/mL) and MCF-7 (IC50 = 3.77 μg/mL) and Vero (IC50:3.65 μg/mL) cells. Compound 6 showed slight cytotoxicity against all tested cancer cell lines. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Research. Vol 31, No.12 (2017), p.1422-1430
dc.identifier.doi10.1080/14786419.2016.1258559
dc.identifier.issn14786419
dc.identifier.other2-s2.0-84996542648
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4817
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.other3beta,5alpha dihydroxyergosta 7,22 dien 6 one
dc.subject.other5 hydroxymethylfurfural
dc.subject.otherAllantoside
dc.subject.otherCerebroside
dc.subject.otherChaxine C
dc.subject.otherCytotoxic agent
dc.subject.otherErgosterol
dc.subject.otherErgosterol epoxide
dc.subject.otherFungal extract
dc.subject.otherMethylcholesta 7,22 diene 3beta,5alpha,6beta triol
dc.subject.otherN [10 (13,14 methylenedioxyphenyl) )pentadienoyl]pyrrolidine
dc.subject.otherNorincisterol A3
dc.subject.otherPiperazine derivative
dc.subject.otherUnclassified drug
dc.subject.otherVeratryl alcohol
dc.subject.otherAntineoplastic agent
dc.subject.otherCerebroside
dc.subject.otherAntineoplastic activity
dc.subject.otherArticle
dc.subject.otherAscomycetes
dc.subject.otherCarbon nuclear magnetic resonance
dc.subject.otherDrug cytotoxicity
dc.subject.otherDrug isolation
dc.subject.otherDrug structure
dc.subject.otherElectrospray mass spectrometry
dc.subject.otherHCT 116 cell line
dc.subject.otherHeLa cell line
dc.subject.otherHeteronuclear multiple bond correlation
dc.subject.otherHT-29 cell line
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIC50
dc.subject.otherInfrared spectroscopy
dc.subject.otherMCF-7 cell line
dc.subject.otherMTT assay
dc.subject.otherProton nuclear magnetic resonance
dc.subject.otherStereochemistry
dc.subject.otherVero cell line
dc.subject.otherXylaria allantoidea
dc.subject.otherChemistry
dc.subject.otherFermentation
dc.subject.otherIsolation and purification
dc.subject.otherMetabolism
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherTumor cell line
dc.subject.otherXylariales
dc.subject.otherAntineoplastic Agents
dc.subject.otherCell Line, Tumor
dc.subject.otherCerebrosides
dc.subject.otherFermentation
dc.subject.otherHumans
dc.subject.otherMagnetic Resonance Spectroscopy
dc.subject.otherXylariales
dc.titleA new cerebroside and the cytotoxic constituents isolated from Xylaria allantoidea SWUF76
dc.typeArticle
dspace.entity.typePublication
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