Publication: A new cerebroside and the cytotoxic constituents isolated from Xylaria allantoidea SWUF76
3
0
Issued Date
2017
Resource Type
File Type
application/pdf
ISSN
14786419
Other identifier(s)
2-s2.0-84996542648
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Natural Product Research. Vol 31, No.12 (2017), p.1422-1430
Suggested Citation
Mccloskey S., Noppawan S., Mongkolthanaruk W., Suwannasai N., Senawong T., Prawat U. A new cerebroside and the cytotoxic constituents isolated from Xylaria allantoidea SWUF76. Natural Product Research. Vol 31, No.12 (2017), p.1422-1430. doi:10.1080/14786419.2016.1258559 Retrieved from: https://hdl.handle.net/20.500.14740/4817
Abstract
A new cerebroside, namely allantoside (1), and 10 known compounds (2–11) were isolated from Xylaria allantoidea SWUF76. The structure of compound 1 was determined by comprehensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance (NMR) as well as high-resolution electron ionisation mass spectrometry (HREIMS) and electrospray ionisation mass spectrometry (ESIMS). Compounds 1, 4, 5, 6, 7, 8 and 11 were evaluated for cytotoxic activities against cancer cell lines (Hela, HT29, HCT116 and MCF-7) and normal Vero cell lines by MTT assay. Compounds 6 and 7 exhibited anticancer activity after 24 h of treatment. Compound 7 showed significant cytotoxicity against Hela (IC50 = 2.24 μg/mL), HT29 (IC50 = 2.51 μg/mL), HCT116 (IC50 = 3.50 μg/mL) and MCF-7 (IC50 = 3.77 μg/mL) and Vero (IC50:3.65 μg/mL) cells. Compound 6 showed slight cytotoxicity against all tested cancer cell lines. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Subject(s)
3beta,5alpha dihydroxyergosta 7,22 dien 6 one
5 hydroxymethylfurfural
Allantoside
Cerebroside
Chaxine C
Cytotoxic agent
Ergosterol
Ergosterol epoxide
Fungal extract
Methylcholesta 7,22 diene 3beta,5alpha,6beta triol
N [10 (13,14 methylenedioxyphenyl) )pentadienoyl]pyrrolidine
Norincisterol A3
Piperazine derivative
Unclassified drug
Veratryl alcohol
Antineoplastic agent
Cerebroside
Antineoplastic activity
Article
Ascomycetes
Carbon nuclear magnetic resonance
Drug cytotoxicity
Drug isolation
Drug structure
Electrospray mass spectrometry
HCT 116 cell line
HeLa cell line
Heteronuclear multiple bond correlation
HT-29 cell line
Human
Human cell
IC50
Infrared spectroscopy
MCF-7 cell line
MTT assay
Proton nuclear magnetic resonance
Stereochemistry
Vero cell line
Xylaria allantoidea
Chemistry
Fermentation
Isolation and purification
Metabolism
Nuclear magnetic resonance spectroscopy
Tumor cell line
Xylariales
Antineoplastic Agents
Cell Line, Tumor
Cerebrosides
Fermentation
Humans
Magnetic Resonance Spectroscopy
Xylariales
5 hydroxymethylfurfural
Allantoside
Cerebroside
Chaxine C
Cytotoxic agent
Ergosterol
Ergosterol epoxide
Fungal extract
Methylcholesta 7,22 diene 3beta,5alpha,6beta triol
N [10 (13,14 methylenedioxyphenyl) )pentadienoyl]pyrrolidine
Norincisterol A3
Piperazine derivative
Unclassified drug
Veratryl alcohol
Antineoplastic agent
Cerebroside
Antineoplastic activity
Article
Ascomycetes
Carbon nuclear magnetic resonance
Drug cytotoxicity
Drug isolation
Drug structure
Electrospray mass spectrometry
HCT 116 cell line
HeLa cell line
Heteronuclear multiple bond correlation
HT-29 cell line
Human
Human cell
IC50
Infrared spectroscopy
MCF-7 cell line
MTT assay
Proton nuclear magnetic resonance
Stereochemistry
Vero cell line
Xylaria allantoidea
Chemistry
Fermentation
Isolation and purification
Metabolism
Nuclear magnetic resonance spectroscopy
Tumor cell line
Xylariales
Antineoplastic Agents
Cell Line, Tumor
Cerebrosides
Fermentation
Humans
Magnetic Resonance Spectroscopy
Xylariales