Publication:
Effects of melatonin on severe crush spinal cord injury–induced reactive astrocyte and scar formation

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dc.contributor.authorKrityakiarana W.
dc.contributor.authorSompup K.
dc.contributor.authorJongkamonwiwat N.
dc.contributor.authorMukda S.
dc.contributor.authorPinilla F.G.
dc.contributor.authorGovitrapong P.
dc.contributor.authorPhansuwan-Pujito P.
dc.date.accessioned2021-04-05T03:23:14Z
dc.date.available2021-04-05T03:23:14Z
dc.date.issued2016
dc.date.issuedBE2559
dc.description.abstractThe present work aimed at analyzing the effects of melatonin on scar formation after spinal cord injury (SCI). Upregulation of reactive astrocyte under SCI pathological conditions has been presented in several studies. It has been proved that the crucial factor in triggering this upregulation is proinflammatory cytokines. Moreover, scar formation is an important barrier to axonal regeneration through the lesion area. Melatonin plays an important role in reducing inflammation, but its effects on scar formation in the injured spinal cord remain unknown. Hence, we used the model of severe crush injury in mice to investigate the effects of melatonin on scar formation. Mice were randomly separated into four groups; SCI, SCI+Melatonin 1 (single dose), SCI+Melatonin 14 (14 daily doses), and control. Melatonin was administered by intraperitoneal injection (10 mg/kg) after injury. Immunohistochemical analysis, Western blot, and behavioral evaluation were used to explore the effects of melatonin after SCI for 14 days. The melatonin-treated mice presented higher expression of neuronal markers (P < 0.001). Remarkably, the inflammatory response appeared to be greatly reduced in the SCI+Melatonin 14 group (P < 0.001), which also displayed less scar formation (P < 0.05). These findings suggest that melatonin inhibits scar formation by acting on inflammatory cytokines after SCI. Overall, our results suggest that melatonin is a promising treatment strategy after SCI that deserves further investigation. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Neuroscience Research. Vol 94, No.12 (2016), p.1451-1459
dc.identifier.doi10.1002/jnr.23930
dc.identifier.issn3604012
dc.identifier.other2-s2.0-84988905763
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4908
dc.rights.holderScopus
dc.subject.otherCytokine
dc.subject.otherMelatonin
dc.subject.otherMelatonin
dc.subject.otherNeuroprotective agent
dc.subject.otherNonsteroid antiinflammatory agent
dc.subject.otherAnimal cell
dc.subject.otherAnimal experiment
dc.subject.otherAnimal model
dc.subject.otherAnimal tissue
dc.subject.otherArticle
dc.subject.otherAstrocyte
dc.subject.otherControlled study
dc.subject.otherDisease control
dc.subject.otherDisease severity
dc.subject.otherDrug effect
dc.subject.otherDrug efficacy
dc.subject.otherFemale
dc.subject.otherImmunohistochemistry
dc.subject.otherMouse
dc.subject.otherNerve crush
dc.subject.otherNervous system inflammation
dc.subject.otherNonhuman
dc.subject.otherOutcome assessment
dc.subject.otherPriority journal
dc.subject.otherRandomized controlled trial
dc.subject.otherScar formation
dc.subject.otherSingle drug dose
dc.subject.otherSpinal cord injury
dc.subject.otherTreatment response
dc.subject.otherWestern blotting
dc.subject.otherAnimal
dc.subject.otherAnimal behavior
dc.subject.otherAstrocyte
dc.subject.otherConvalescence
dc.subject.otherDrug effects
dc.subject.otherLocomotion
dc.subject.otherMetabolism
dc.subject.otherNerve crush
dc.subject.otherPathology
dc.subject.otherPsychology
dc.subject.otherScar
dc.subject.otherSpinal cord injury
dc.subject.otherAnimals
dc.subject.otherAnti-Inflammatory Agents, Non-Steroidal
dc.subject.otherAstrocytes
dc.subject.otherBehavior, Animal
dc.subject.otherCicatrix
dc.subject.otherFemale
dc.subject.otherLocomotion
dc.subject.otherMelatonin
dc.subject.otherMice
dc.subject.otherNerve Crush
dc.subject.otherNeuroprotective Agents
dc.subject.otherRecovery of Function
dc.subject.otherSpinal Cord Injuries
dc.titleEffects of melatonin on severe crush spinal cord injury–induced reactive astrocyte and scar formation
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84988905763&doi=10.1002%2fjnr.23930&partnerID=40&md5=c3d1b31cc12f30ee81acf462bc02bdea

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