Publication:
Disulfide-linked liposomes: Effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139

Simple item page
dc.contributor.authorWeecharangsan W.
dc.contributor.authorYu B.
dc.contributor.authorLiu S.
dc.contributor.authorPang J.X.
dc.contributor.authorLee L.J.
dc.contributor.authorMarcucci G.
dc.contributor.authorLee R.J.
dc.date.accessioned2021-04-05T03:37:05Z
dc.date.available2021-04-05T03:37:05Z
dc.date.issued2010
dc.date.issuedBE2553
dc.description.abstractBackground: Disulfide-linked oligodeoxyribonucleotide (ODN) liposomes were formulated and evaluated for the delivery of antisense ODN G3139 in KB human oral carcinoma cells. Materials and Methods: Liposomes composed of 1,2-di-(9Z-octadecenoyl)-3-trimethylammo-nium-propane(DOTAP)/egg phosphatidylcholine/α-tocopheryl polyethylene glycol 1000 succinate were incorporated with hydrophobized disulfide-linked ODN. Disulfide-linked ODN liposomes were characterized for their size, ODN intracellular delivery, Bcl-2 mRNA and protein expression, growth inhibition, and chemosensitization. Results: Intracellular delivery of ODN with disulfide-linked ODN liposomes was more efficient than that with non-liposomal hydrophobized disulfide-linked ODN. Treatment of the cells with disulfide-linked ODN liposomes resulted in efficient Bcl-2 down-regulation greater than that with hydrophobized disulfide-linked ODN and consistent with that of cellular growth inhibition and the sensitization to daunorubicin in KB cells. Disulfide-linked ODN liposomes exhibited superior colloidal stability during 5-week storage. Conclusion: Disulfide-linked liposomes are effective delivery vehicles for antisense ODN.
dc.format.mimetypeapplication/pdf
dc.identifier.citationAnticancer Research. Vol 30, No.1 (2010), p.31-38
dc.identifier.issn2507005
dc.identifier.other2-s2.0-77649246832
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7666
dc.rights.holderScopus
dc.subject.other1,2 dioleoyl 3 trimethylammoniopropane
dc.subject.otherDaunorubicin
dc.subject.otherDisulfide linked liposome
dc.subject.otherLiposome
dc.subject.otherMacrogol derivative
dc.subject.otherMessenger RNA
dc.subject.otherOblimersen
dc.subject.otherPhosphatidylcholine
dc.subject.otherPolyethylene glycol 1000 succinate
dc.subject.otherProtein bcl 2
dc.subject.otherUnclassified drug
dc.subject.otherArticle
dc.subject.otherCell growth
dc.subject.otherCell strain KB
dc.subject.otherChemosensitization
dc.subject.otherControlled study
dc.subject.otherDown regulation
dc.subject.otherGrowth inhibition
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIntracellular transport
dc.subject.otherMouth carcinoma
dc.subject.otherNonviral gene delivery system
dc.subject.otherPriority journal
dc.subject.otherProtein expression
dc.subject.otherAntibiotics, Antineoplastic
dc.subject.otherCell Growth Processes
dc.subject.otherColloids
dc.subject.otherDaunorubicin
dc.subject.otherDisulfides
dc.subject.otherDown-Regulation
dc.subject.otherDrug Stability
dc.subject.otherGenes, bcl-2
dc.subject.otherHumans
dc.subject.otherKB Cells
dc.subject.otherLiposomes
dc.subject.otherOligodeoxyribonucleotides, Antisense
dc.subject.otherTransfection
dc.titleDisulfide-linked liposomes: Effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77649246832&partnerID=40&md5=58a80b4e5e45b2b1ee0f7b97fed14f3f

Files

Collections

Scopus: Year 1983-2021