Publication: Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis
0
0
Issued Date
2006
Resource Type
File Type
application/pdf
ISSN
14243210
DOI
Other identifier(s)
2-s2.0-33947367459
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Sensors. Vol 6, No.12 (2006), p.1837-1850
Suggested Citation
Karuwan C., Mantim T., Chaisuwan P., Wilairat P., Grudpan K., Jittangprasert P., Einaga Y., Chailapakul O., Suntornsuk L., Anurukvorakun O., Nacapricha D. Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis. Sensors. Vol 6, No.12 (2006), p.1837-1850. doi:10.3390/s6121837 Retrieved from: https://hdl.handle.net/20.500.14740/6002
Abstract
This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method. © 2006 by MDPI.