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GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

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dc.contributor.authorWangchuk P.
dc.contributor.authorKeller P.A.
dc.contributor.authorPyne S.G.
dc.contributor.authorTaweechotipatr M.
dc.contributor.authorKamchonwongpaisan S.
dc.date.accessioned2021-04-05T03:32:50Z
dc.date.available2021-04-05T03:32:50Z
dc.date.issued2013
dc.date.issuedBE2556
dc.description.abstractWe have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analysis followed by testing for bioactivity. The GC-MS analysis identified 52 compounds with (E)-isomyristicin as a major component (32.2%). Repeated purification yielded four compounds; (E)-isomyristicin (1), (E)-isoapiol (2), methyl eugenol (3) and (E)-isoelemicin (4). Compound 2 and the mother EO showed the best antiplasmodial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). They exhibited mild antibacterial activity against Bacillus subtilis. None of the test samples showed cytotoxicity.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Communications. Vol 8, No.9 (2013), p.1305-1308
dc.identifier.doi10.1177/1934578x1300800930
dc.identifier.issn1934578X
dc.identifier.other2-s2.0-84886805648
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6567
dc.rights.holderScopus
dc.subject.otherAntiinfective agent
dc.subject.otherAntimalarial agent
dc.subject.otherApiole
dc.subject.otherElemicin
dc.subject.otherEssential oil
dc.subject.otherHerbaceous agent
dc.subject.otherIsoapiol
dc.subject.otherIsoelemicin
dc.subject.otherIsomyristicin
dc.subject.otherMethyleugenol
dc.subject.otherMyristicin
dc.subject.otherUnclassified drug
dc.subject.otherAntibacterial activity
dc.subject.otherAntimalarial activity
dc.subject.otherArticle
dc.subject.otherBacillus subtilis
dc.subject.otherCarbon nuclear magnetic resonance
dc.subject.otherControlled study
dc.subject.otherCytotoxicity
dc.subject.otherMass fragmentography
dc.subject.otherNonhuman
dc.subject.otherPlasmodium falciparum
dc.subject.otherPleurospermum amabile
dc.subject.otherTripleurospermum
dc.subject.otherBacillus subtilis
dc.subject.otherPlasmodium falciparum
dc.subject.otherPleurospermum
dc.titleGC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84886805648&doi=10.1177%2f1934578x1300800930&partnerID=40&md5=f265cc589fc1d03b4f2c288a3adec18f

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