Publication:
GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

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Issued Date

2013

Resource Type

Article

File Type

application/pdf

ISSN

1934578X

DOI

10.1177/1934578x1300800930

Other identifier(s)

2-s2.0-84886805648

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Communications. Vol 8, No.9 (2013), p.1305-1308

Suggested Citation

Wangchuk P., Keller P.A., Pyne S.G., Taweechotipatr M., Kamchonwongpaisan S. GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile. Natural Product Communications. Vol 8, No.9 (2013), p.1305-1308. doi:10.1177/1934578x1300800930 Retrieved from: https://hdl.handle.net/20.500.14740/6567

Title

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

Author(s)

Wangchuk P.
 Keller P.A.
 Pyne S.G.
 Taweechotipatr M.
 Kamchonwongpaisan S.

Abstract

We have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analysis followed by testing for bioactivity. The GC-MS analysis identified 52 compounds with (E)-isomyristicin as a major component (32.2%). Repeated purification yielded four compounds; (E)-isomyristicin (1), (E)-isoapiol (2), methyl eugenol (3) and (E)-isoelemicin (4). Compound 2 and the mother EO showed the best antiplasmodial activity against the Plasmodium falciparum strains, TM4/8.2 (chloroquine and antifolate sensitive) and K1CB1 (multidrug resistant). They exhibited mild antibacterial activity against Bacillus subtilis. None of the test samples showed cytotoxicity.

Subject(s)

Antiinfective agent
 Antimalarial agent
 Apiole
 Elemicin
 Essential oil
 Herbaceous agent
 Isoapiol
 Isoelemicin
 Isomyristicin
 Methyleugenol
 Myristicin
 Unclassified drug
 Antibacterial activity
 Antimalarial activity
 Article
 Bacillus subtilis
 Carbon nuclear magnetic resonance
 Controlled study
 Cytotoxicity
 Mass fragmentography
 Nonhuman
 Plasmodium falciparum
 Pleurospermum amabile
 Tripleurospermum
 Bacillus subtilis
 Plasmodium falciparum
 Pleurospermum

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URI

https://hdl.handle.net/20.500.14740/6567

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Scopus: Year 1983-2021

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