Publication:
Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats

Simple item page
dc.contributor.authorSuwanjang W.
dc.contributor.authorRuankham W.
dc.contributor.authorChetsawang B.
dc.contributor.authorMukda S.
dc.contributor.authorNgampramuan S.
dc.contributor.authorSrisung S.
dc.contributor.authorPrachayasittikul V.
dc.contributor.authorPrachayasittikul S.
dc.date.accessioned2022-03-10T13:16:37Z
dc.date.available2022-03-10T13:16:37Z
dc.date.issued2021
dc.date.issuedBE2564
dc.description.abstractChronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function. © 2021 Elsevier Ltd
dc.format.mimetypeapplication/pdf
dc.identifier.citationNeurochemistry International. Vol 148, No. (2021)
dc.identifier.doi10.1016/j.neuint.2021.105083
dc.identifier.issn1970186
dc.identifier.other2-s2.0-85107303542
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4167
dc.language.isoeng
dc.rights.holderScopus
dc.subject.otherAcetic acid ethyl ester
dc.subject.otherAntidepressant agent
dc.subject.otherChaperonin 60
dc.subject.otherManganese superoxide dismutase
dc.subject.otherPlant extract
dc.subject.otherProton transporting adenosine triphosphate synthase
dc.subject.otherSpilanthes acmella extract
dc.subject.otherUnclassified drug
dc.subject.otherAntioxidant
dc.subject.otherChaperonin 60
dc.subject.otherHspd1 protein, rat
dc.subject.otherMitochondrial protein
dc.subject.otherPlant extract
dc.subject.otherAdult
dc.subject.otherAnimal experiment
dc.subject.otherAnimal model
dc.subject.otherArticle
dc.subject.otherBody weight
dc.subject.otherChronic stress
dc.subject.otherControlled study
dc.subject.otherDepression
dc.subject.otherForced swim test
dc.subject.otherHippocampus
dc.subject.otherImmobilization stress
dc.subject.otherMale
dc.subject.otherMitochondrial dynamics
dc.subject.otherMorris water maze test
dc.subject.otherNonhuman
dc.subject.otherPrefrontal cortex
dc.subject.otherPriority journal
dc.subject.otherProtein expression
dc.subject.otherRat
dc.subject.otherSpilanthes acmella
dc.subject.otherAnimal
dc.subject.otherAnimal behavior
dc.subject.otherAsteraceae
dc.subject.otherBiosynthesis
dc.subject.otherChemistry
dc.subject.otherChronic disease
dc.subject.otherCognition
dc.subject.otherDrug effect
dc.subject.otherExercise
dc.subject.otherGenetics
dc.subject.otherMedicinal plant
dc.subject.otherMental stress
dc.subject.otherMetabolism
dc.subject.otherMitochondrial dynamics
dc.subject.otherMitochondrion
dc.subject.otherPsychology
dc.subject.otherSprague Dawley rat
dc.subject.otherAnimals
dc.subject.otherAntioxidants
dc.subject.otherAsteraceae
dc.subject.otherBehavior, Animal
dc.subject.otherChaperonin 60
dc.subject.otherChronic Disease
dc.subject.otherCognition
dc.subject.otherDepression
dc.subject.otherHippocampus
dc.subject.otherMale
dc.subject.otherMitochondria
dc.subject.otherMitochondrial Dynamics
dc.subject.otherMitochondrial Proteins
dc.subject.otherPlant Extracts
dc.subject.otherPlants, Medicinal
dc.subject.otherRats
dc.subject.otherRats, Sprague-Dawley
dc.subject.otherRestraint, Physical
dc.subject.otherStress, Psychological
dc.titleSpilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85107303542&doi=10.1016%2fj.neuint.2021.105083&partnerID=40&md5=79f1841f937420d7dcd22ce1e9b6af83

Files

Collections

Scopus: Year 1983-2021