Publication:
Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats

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Issued Date

2021

Resource Type

Article

Language

eng

File Type

application/pdf

ISSN

1970186

DOI

10.1016/j.neuint.2021.105083

Other identifier(s)

2-s2.0-85107303542

Rights Holder(s)

Scopus

Bibliographic Citation

Neurochemistry International. Vol 148, No. (2021)

Suggested Citation

Suwanjang W., Ruankham W., Chetsawang B., Mukda S., Ngampramuan S., Srisung S., Prachayasittikul V., Prachayasittikul S. Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats. Neurochemistry International. Vol 148, No. (2021). doi:10.1016/j.neuint.2021.105083 Retrieved from: https://hdl.handle.net/20.500.14740/4167

Title

Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats

Author(s)

Suwanjang W.
 Ruankham W.
 Chetsawang B.
 Mukda S.
 Ngampramuan S.
 Srisung S.
 Prachayasittikul V.
 Prachayasittikul S.

Abstract

Chronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function. © 2021 Elsevier Ltd

Subject(s)

Acetic acid ethyl ester
 Antidepressant agent
 Chaperonin 60
 Manganese superoxide dismutase
 Plant extract
 Proton transporting adenosine triphosphate synthase
 Spilanthes acmella extract
 Unclassified drug
 Antioxidant
 Chaperonin 60
 Hspd1 protein, rat
 Mitochondrial protein
 Plant extract
 Adult
 Animal experiment
 Animal model
 Article
 Body weight
 Chronic stress
 Controlled study
 Depression
 Forced swim test
 Hippocampus
 Immobilization stress
 Male
 Mitochondrial dynamics
 Morris water maze test
 Nonhuman
 Prefrontal cortex
 Priority journal
 Protein expression
 Rat
 Spilanthes acmella
 Animal
 Animal behavior
 Asteraceae
 Biosynthesis
 Chemistry
 Chronic disease
 Cognition
 Drug effect
 Exercise
 Genetics
 Medicinal plant
 Mental stress
 Metabolism
 Mitochondrial dynamics
 Mitochondrion
 Psychology
 Sprague Dawley rat
 Animals
 Antioxidants
 Asteraceae
 Behavior, Animal
 Chaperonin 60
 Chronic Disease
 Cognition
 Depression
 Hippocampus
 Male
 Mitochondria
 Mitochondrial Dynamics
 Mitochondrial Proteins
 Plant Extracts
 Plants, Medicinal
 Rats
 Rats, Sprague-Dawley
 Restraint, Physical
 Stress, Psychological

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URI

https://hdl.handle.net/20.500.14740/4167

Collections

Scopus: Year 1983-2021

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