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Antimycobacterial and antioxidant flavones from Limnophila geoffrayi

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dc.contributor.authorSuksamrarn A.
dc.contributor.authorPoomsing P.
dc.contributor.authorAroonrerk N.
dc.contributor.authorPunjanon T.
dc.contributor.authorSuksamrarn S.
dc.contributor.authorKongkun S.
dc.date.accessioned2021-04-05T04:32:50Z
dc.date.available2021-04-05T04:32:50Z
dc.date.issued2003
dc.date.issuedBE2546
dc.description.abstractThe chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4′- trimethoxyflavone, 1) and isothymusin (6,7-dimethoxy-5,8,4′- trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 mg/mL. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC50 value of 7.7 μg/mL. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.
dc.format.mimetypeapplication/pdf
dc.identifier.citationArchives of Pharmacal Research. Vol 26, No.10 (2003), p.816-820
dc.identifier.doi10.1007/BF02980026
dc.identifier.issn2536269
dc.identifier.other2-s2.0-23844456380
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6522
dc.rights.holderScopus
dc.subject.otherAntiinfective agent
dc.subject.otherAntioxidant
dc.subject.otherChloroform
dc.subject.otherFlavone derivative
dc.subject.otherFlavonoid
dc.subject.otherIsothymusin
dc.subject.otherNevadensin
dc.subject.otherPlant extract
dc.subject.otherArticle
dc.subject.otherBacillus subtilis
dc.subject.otherChemical structure
dc.subject.otherChemistry
dc.subject.otherDrug effect
dc.subject.otherGenetics
dc.subject.otherIsolation and purification
dc.subject.otherMethodology
dc.subject.otherMicrobiological examination
dc.subject.otherMutagen testing
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherPhysiology
dc.subject.otherPlant leaf
dc.subject.otherPlant stem
dc.subject.otherScrophulariaceae
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherAntioxidants
dc.subject.otherBacillus subtilis
dc.subject.otherChloroform
dc.subject.otherFlavones
dc.subject.otherFlavonoids
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherMolecular Structure
dc.subject.otherMutagenicity Tests
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherPlant Extracts
dc.subject.otherPlant Leaves
dc.subject.otherPlant Stems
dc.subject.otherScrophulariaceae
dc.titleAntimycobacterial and antioxidant flavones from Limnophila geoffrayi
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-23844456380&doi=10.1007%2fBF02980026&partnerID=40&md5=27d205feb26d9d8f603dede49430a0d1

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