Publication:
Antimycobacterial and antioxidant flavones from Limnophila geoffrayi

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Issued Date

2003

Resource Type

Article

File Type

application/pdf

ISSN

2536269

DOI

10.1007/BF02980026

Other identifier(s)

2-s2.0-23844456380

Rights Holder(s)

Scopus

Bibliographic Citation

Archives of Pharmacal Research. Vol 26, No.10 (2003), p.816-820

Suggested Citation

Suksamrarn A., Poomsing P., Aroonrerk N., Punjanon T., Suksamrarn S., Kongkun S. Antimycobacterial and antioxidant flavones from Limnophila geoffrayi. Archives of Pharmacal Research. Vol 26, No.10 (2003), p.816-820. doi:10.1007/BF02980026 Retrieved from: https://hdl.handle.net/20.500.14740/6522

Title

Antimycobacterial and antioxidant flavones from Limnophila geoffrayi

Author(s)

Suksamrarn A.
 Poomsing P.
 Aroonrerk N.
 Punjanon T.
 Suksamrarn S.
 Kongkun S.

Abstract

The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4′- trimethoxyflavone, 1) and isothymusin (6,7-dimethoxy-5,8,4′- trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 mg/mL. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the IC50 value of 7.7 μg/mL. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.

Subject(s)

Antiinfective agent
 Antioxidant
 Chloroform
 Flavone derivative
 Flavonoid
 Isothymusin
 Nevadensin
 Plant extract
 Article
 Bacillus subtilis
 Chemical structure
 Chemistry
 Drug effect
 Genetics
 Isolation and purification
 Methodology
 Microbiological examination
 Mutagen testing
 Mycobacterium tuberculosis
 Physiology
 Plant leaf
 Plant stem
 Scrophulariaceae
 Anti-Bacterial Agents
 Antioxidants
 Bacillus subtilis
 Chloroform
 Flavones
 Flavonoids
 Microbial Sensitivity Tests
 Molecular Structure
 Mutagenicity Tests
 Mycobacterium tuberculosis
 Plant Extracts
 Plant Leaves
 Plant Stems
 Scrophulariaceae

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URI

https://hdl.handle.net/20.500.14740/6522

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Scopus: Year 1983-2021

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