Publication:
OPCML gene as a schizophrenia susceptibility locus in Thai population.

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dc.contributor.authorPanichareon B.
dc.contributor.authorNakayama K.
dc.contributor.authorThurakitwannakarn W.
dc.contributor.authorIwamoto S.
dc.contributor.authorSukhumsirichart W.
dc.date.accessioned2021-04-05T03:34:33Z
dc.date.available2021-04-05T03:34:33Z
dc.date.issued2012
dc.date.issuedBE2555
dc.description.abstractOpioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57-2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44-0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of molecular neuroscience : MN. Vol 46, No.2 (2012), p.373-377
dc.identifier.doi10.1007/s12031-011-9595-2
dc.identifier.issn15591166
dc.identifier.other2-s2.0-84866166274
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7117
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherCell adhesion molecule
dc.subject.otherGlycosylphosphatidylinositol anchored protein
dc.subject.otherOPCML protein, human
dc.subject.otherAdult
dc.subject.otherArticle
dc.subject.otherComparative study
dc.subject.otherDNA denaturation
dc.subject.otherEthnic group
dc.subject.otherEthnology
dc.subject.otherFemale
dc.subject.otherGene frequency
dc.subject.otherGenetic predisposition
dc.subject.otherGenetics
dc.subject.otherGenotype
dc.subject.otherHuman
dc.subject.otherIntron
dc.subject.otherMale
dc.subject.otherMiddle aged
dc.subject.otherPhysiology
dc.subject.otherPolymerase chain reaction
dc.subject.otherRisk
dc.subject.otherSchizophrenia
dc.subject.otherSingle nucleotide polymorphism
dc.subject.otherThailand
dc.subject.otherAdult
dc.subject.otherCell Adhesion Molecules
dc.subject.otherEthnic Groups
dc.subject.otherFemale
dc.subject.otherGene Frequency
dc.subject.otherGenetic Predisposition to Disease
dc.subject.otherGenotype
dc.subject.otherGPI-Linked Proteins
dc.subject.otherHumans
dc.subject.otherIntrons
dc.subject.otherMale
dc.subject.otherMiddle Aged
dc.subject.otherNucleic Acid Denaturation
dc.subject.otherPolymerase Chain Reaction
dc.subject.otherPolymorphism, Single Nucleotide
dc.subject.otherRisk
dc.subject.otherSchizophrenia
dc.subject.otherThailand
dc.titleOPCML gene as a schizophrenia susceptibility locus in Thai population.
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84866166274&doi=10.1007%2fs12031-011-9595-2&partnerID=40&md5=10364b41dc16fed9eb8e0066ccc53f96

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