Publication:
OPCML gene as a schizophrenia susceptibility locus in Thai population.

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Issued Date

2012

Resource Type

Article

File Type

application/pdf

ISSN

15591166

DOI

10.1007/s12031-011-9595-2

Other identifier(s)

2-s2.0-84866166274

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Journal of molecular neuroscience : MN. Vol 46, No.2 (2012), p.373-377

Suggested Citation

Panichareon B., Nakayama K., Thurakitwannakarn W., Iwamoto S., Sukhumsirichart W. OPCML gene as a schizophrenia susceptibility locus in Thai population.. Journal of molecular neuroscience : MN. Vol 46, No.2 (2012), p.373-377. doi:10.1007/s12031-011-9595-2 Retrieved from: https://hdl.handle.net/20.500.14740/7117

Title

OPCML gene as a schizophrenia susceptibility locus in Thai population.

Author(s)

Panichareon B.
 Nakayama K.
 Thurakitwannakarn W.
 Iwamoto S.
 Sukhumsirichart W.

Abstract

Opioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57-2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44-0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.

Subject(s)

Cell adhesion molecule
 Glycosylphosphatidylinositol anchored protein
 OPCML protein, human
 Adult
 Article
 Comparative study
 DNA denaturation
 Ethnic group
 Ethnology
 Female
 Gene frequency
 Genetic predisposition
 Genetics
 Genotype
 Human
 Intron
 Male
 Middle aged
 Physiology
 Polymerase chain reaction
 Risk
 Schizophrenia
 Single nucleotide polymorphism
 Thailand
 Adult
 Cell Adhesion Molecules
 Ethnic Groups
 Female
 Gene Frequency
 Genetic Predisposition to Disease
 Genotype
 GPI-Linked Proteins
 Humans
 Introns
 Male
 Middle Aged
 Nucleic Acid Denaturation
 Polymerase Chain Reaction
 Polymorphism, Single Nucleotide
 Risk
 Schizophrenia
 Thailand

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URI

https://hdl.handle.net/20.500.14740/7117

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Scopus: Year 1983-2021

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