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Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37

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dc.contributor.authorNoppawan S.
dc.contributor.authorMongkolthanaruk W.
dc.contributor.authorSuwannasai N.
dc.contributor.authorSenawong T.
dc.contributor.authorMoontragoon P.
dc.contributor.authorBoonmak J.
dc.contributor.authorYoungme S.
dc.contributor.authorMccloskey S.
dc.date.accessioned2021-04-05T03:01:36Z
dc.date.available2021-04-05T03:01:36Z
dc.date.issued2020
dc.date.issuedBE2563
dc.description.abstractA new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50 = 19.60 µg/mL), HT29 (IC50 = 17.31 µg/mL), HCT116 (IC50 = 14.28 µg/mL), MCF-7 (IC50 = 15.38 µg/mL), and Vero (IC50 = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Research. Vol 34, No.4 (2020), p.464-473
dc.identifier.doi10.1080/14786419.2018.1488709
dc.identifier.issn14786419
dc.identifier.other2-s2.0-85053874640
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4650
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherCytochalasin
dc.subject.otherFungal extract
dc.subject.otherPentaminolarin
dc.subject.otherPentapeptide
dc.subject.otherXylochalasin
dc.subject.otherAntineoplastic agent
dc.subject.otherCyclopeptide
dc.subject.otherCytochalasin
dc.subject.otherControlled study
dc.subject.otherCytotoxicity
dc.subject.otherDensity functional theory
dc.subject.otherDrug purification
dc.subject.otherDrug structure
dc.subject.otherHCT 116 cell line
dc.subject.otherHeLa cell line
dc.subject.otherHT-29 cell line
dc.subject.otherHuman
dc.subject.otherHuman cell
dc.subject.otherIC50
dc.subject.otherMTT assay
dc.subject.otherNonhuman
dc.subject.otherThailand
dc.subject.otherVero cell line
dc.subject.otherXylariales
dc.subject.otherChemistry
dc.subject.otherConformation
dc.subject.otherDrug screening
dc.subject.otherIsolation and purification
dc.subject.otherPathogenicity
dc.subject.otherTumor cell line
dc.subject.otherAntineoplastic Agents
dc.subject.otherCell Line, Tumor
dc.subject.otherCytochalasins
dc.subject.otherDrug Screening Assays, Antitumor
dc.subject.otherHumans
dc.subject.otherMolecular Conformation
dc.subject.otherPeptides, Cyclic
dc.subject.otherXylariales
dc.titleChemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85053874640&doi=10.1080%2f14786419.2018.1488709&partnerID=40&md5=09eec464f381ef64953383ac92d1500f

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