Publication:
Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37

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0

Issued Date

2020

Resource Type

Article

File Type

application/pdf

ISSN

14786419

DOI

10.1080/14786419.2018.1488709

Other identifier(s)

2-s2.0-85053874640

Rights Holder(s)

มหาวิทยาลัยศรีนครินทรวิโรฒ

Bibliographic Citation

Natural Product Research. Vol 34, No.4 (2020), p.464-473

Suggested Citation

Noppawan S., Mongkolthanaruk W., Suwannasai N., Senawong T., Moontragoon P., Boonmak J., Youngme S., Mccloskey S. Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37. Natural Product Research. Vol 34, No.4 (2020), p.464-473. doi:10.1080/14786419.2018.1488709 Retrieved from: https://hdl.handle.net/20.500.14740/4650

Title

Chemical constituents and cytotoxic activity from the wood-decaying fungus Xylaria sp. SWUF08-37

Author(s)

Noppawan S.
 Mongkolthanaruk W.
 Suwannasai N.
 Senawong T.
 Moontragoon P.
 Boonmak J.
 Youngme S.
 Mccloskey S.

Abstract

A new cyclic pentapeptide, pentaminolarin (1), and a new cytochalasin, xylochalasin (2), along with thirteen known compounds (3–15) were isolated from the wood-decaying fungus Xylaria sp. SWUF08-37. The absolute configurations of 1 were determined by a combination of Marfey’s method and TDDFT ECD calculation and the absolute configurations of 2 were established by TDDFT ECD calculation. Compound 12 showed moderate cytotoxicity against HeLa (IC50 = 19.60 µg/mL), HT29 (IC50 = 17.31 µg/mL), HCT116 (IC50 = 14.28 µg/mL), MCF-7 (IC50 = 15.38 µg/mL), and Vero (IC50 = 24.97 µg/mL) cell lines by MTT assay. Compounds 1 and 2 showed slight cytotoxicity against all tested cancer cell lines. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Subject(s)

Cytochalasin
 Fungal extract
 Pentaminolarin
 Pentapeptide
 Xylochalasin
 Antineoplastic agent
 Cyclopeptide
 Cytochalasin
 Controlled study
 Cytotoxicity
 Density functional theory
 Drug purification
 Drug structure
 HCT 116 cell line
 HeLa cell line
 HT-29 cell line
 Human
 Human cell
 IC50
 MTT assay
 Nonhuman
 Thailand
 Vero cell line
 Xylariales
 Chemistry
 Conformation
 Drug screening
 Isolation and purification
 Pathogenicity
 Tumor cell line
 Antineoplastic Agents
 Cell Line, Tumor
 Cytochalasins
 Drug Screening Assays, Antitumor
 Humans
 Molecular Conformation
 Peptides, Cyclic
 Xylariales

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URI

https://hdl.handle.net/20.500.14740/4650

Collections

Scopus: Year 1983-2021

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