Publication:
Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA

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dc.contributor.authorYingyongnarongkul B.-E.
dc.contributor.authorApiratikul N.
dc.contributor.authorAroonrerk N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:31:59Z
dc.date.available2021-04-05T04:31:59Z
dc.date.issued2008
dc.date.issuedBE2551
dc.description.abstractBis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl) polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells. © 2008 The Pharmaceutical Society of Korea.
dc.format.mimetypeapplication/pdf
dc.identifier.citationArchives of Pharmacal Research. Vol 31, No.6 (2008), p.698-704
dc.identifier.doi10.1007/s12272-001-1215-4
dc.identifier.issn2536269
dc.identifier.other2-s2.0-45749097459
dc.identifier.urihttps://hdl.handle.net/20.500.14740/4010
dc.rights.holderScopus
dc.subject.other3,4-dihydroxyphenylpropionic acid
dc.subject.otherAntiinfective agent
dc.subject.otherCaffeic acid derivative
dc.subject.otherDihydrocaffeic acid
dc.subject.otherDrug derivative
dc.subject.otherSpermidine
dc.subject.otherAnimal
dc.subject.otherAntibiotic resistance
dc.subject.otherArticle
dc.subject.otherCell survival
dc.subject.otherCercopithecus
dc.subject.otherChemical structure
dc.subject.otherDose response
dc.subject.otherDrug effect
dc.subject.otherGrowth, development and aging
dc.subject.otherIC 50
dc.subject.otherMicrobiological examination
dc.subject.otherPenicillin resistance
dc.subject.otherStaphylococcus aureus
dc.subject.otherSynthesis
dc.subject.otherVero cell
dc.subject.otherAnimals
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherCaffeic Acids
dc.subject.otherCell Survival
dc.subject.otherCercopithecus aethiops
dc.subject.otherDose-Response Relationship, Drug
dc.subject.otherInhibitory Concentration 50
dc.subject.otherMethicillin Resistance
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherMolecular Structure
dc.subject.otherSpermidine
dc.subject.otherStaphylococcus aureus
dc.subject.otherVancomycin Resistance
dc.subject.otherVero Cells
dc.titleSynthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-45749097459&doi=10.1007%2fs12272-001-1215-4&partnerID=40&md5=9d9df22ae5f6bc2755552008dc25c54d

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