Publication:
Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA

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Issued Date

2008

Resource Type

Article

File Type

application/pdf

ISSN

2536269

DOI

10.1007/s12272-001-1215-4

Other identifier(s)

2-s2.0-45749097459

Rights Holder(s)

Scopus

Bibliographic Citation

Archives of Pharmacal Research. Vol 31, No.6 (2008), p.698-704

Suggested Citation

Yingyongnarongkul B.-E., Apiratikul N., Aroonrerk N., Suksamrarn A. Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA. Archives of Pharmacal Research. Vol 31, No.6 (2008), p.698-704. doi:10.1007/s12272-001-1215-4 Retrieved from: https://hdl.handle.net/20.500.14740/4010

Title

Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA

Author(s)

Yingyongnarongkul B.-E.
 Apiratikul N.
 Aroonrerk N.
 Suksamrarn A.

Abstract

Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl) polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells. © 2008 The Pharmaceutical Society of Korea.

Subject(s)

3,4-dihydroxyphenylpropionic acid
 Antiinfective agent
 Caffeic acid derivative
 Dihydrocaffeic acid
 Drug derivative
 Spermidine
 Animal
 Antibiotic resistance
 Article
 Cell survival
 Cercopithecus
 Chemical structure
 Dose response
 Drug effect
 Growth, development and aging
 IC 50
 Microbiological examination
 Penicillin resistance
 Staphylococcus aureus
 Synthesis
 Vero cell
 Animals
 Anti-Bacterial Agents
 Caffeic Acids
 Cell Survival
 Cercopithecus aethiops
 Dose-Response Relationship, Drug
 Inhibitory Concentration 50
 Methicillin Resistance
 Microbial Sensitivity Tests
 Molecular Structure
 Spermidine
 Staphylococcus aureus
 Vancomycin Resistance
 Vero Cells

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URI

https://hdl.handle.net/20.500.14740/4010

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Scopus: Year 1983-2021

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