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Method of preparation does not affect the miscibility between steroid hormone and polymethacrylate

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dc.contributor.authorWiranidchapong C.
dc.contributor.authorRades T.
dc.contributor.authorKulvanich P.
dc.contributor.authorTucker I.G.
dc.date.accessioned2021-04-05T04:33:55Z
dc.date.available2021-04-05T04:33:55Z
dc.date.issued2009
dc.date.issuedBE2552
dc.description.abstractMiscibility of 17β-estradiol in Eudragit® RS and norethindrone in Eudragit® RS either physical mixes or solid dispersions was determined by modulated temperature differential scanning calorimetry using three heating programs. Heating program I-E revealed the melting point depression of 17β-estradiol in Eudragit® RS as a function of composition, estimated by the Nishi-Wang equation. Heating program II-E disclosed a single glass transition temperature of the blends lying between those of 17β-estradiol and Eudragit® RS, described by the Kwei equation. Heating program I-N demonstrated the reduction of norethindrone melting point when the concentration of Eudragit® RS increased. The parameters determined by the Nishi-Wang and Kwei fits were consistent with the interactions between blend components. No difference in the miscibility and interactions between blend components was observed in the blends prepared by physical mixes and co-evaporation. © 2008 Elsevier B.V. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.identifier.citationThermochimica Acta. Vol 485, (2009), p.57-64
dc.identifier.doi10.1016/j.tca.2008.12.013
dc.identifier.issn406031
dc.identifier.other2-s2.0-59849091498
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7495
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.otherDifferential scanning calorimetry
dc.subject.otherDrug interactions
dc.subject.otherFourier transform infrared spectroscopy
dc.subject.otherGlass transition
dc.subject.otherHeating
dc.subject.otherHormones
dc.subject.otherMelting
dc.subject.otherPolymer blends
dc.subject.otherPolymer melts
dc.subject.otherRapid solidification
dc.subject.otherSteelmaking
dc.subject.otherThermochemistry
dc.subject.otherDrug-polymer interaction
dc.subject.otherFTIR
dc.subject.otherMelting point depression
dc.subject.otherMTDSC
dc.subject.otherPolymethacrylate
dc.subject.otherSteroid hormone
dc.subject.otherMelting point
dc.titleMethod of preparation does not affect the miscibility between steroid hormone and polymethacrylate
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-59849091498&doi=10.1016%2fj.tca.2008.12.013&partnerID=40&md5=0fe856594972b083eb69bfa7a180abe7

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