Publication: Method of preparation does not affect the miscibility between steroid hormone and polymethacrylate
0
0
Issued Date
2009
Resource Type
File Type
application/pdf
ISSN
406031
Other identifier(s)
2-s2.0-59849091498
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Thermochimica Acta. Vol 485, (2009), p.57-64
Suggested Citation
Wiranidchapong C., Rades T., Kulvanich P., Tucker I.G. Method of preparation does not affect the miscibility between steroid hormone and polymethacrylate. Thermochimica Acta. Vol 485, (2009), p.57-64. doi:10.1016/j.tca.2008.12.013 Retrieved from: https://hdl.handle.net/20.500.14740/7495
Author(s)
Abstract
Miscibility of 17β-estradiol in Eudragit® RS and norethindrone in Eudragit® RS either physical mixes or solid dispersions was determined by modulated temperature differential scanning calorimetry using three heating programs. Heating program I-E revealed the melting point depression of 17β-estradiol in Eudragit® RS as a function of composition, estimated by the Nishi-Wang equation. Heating program II-E disclosed a single glass transition temperature of the blends lying between those of 17β-estradiol and Eudragit® RS, described by the Kwei equation. Heating program I-N demonstrated the reduction of norethindrone melting point when the concentration of Eudragit® RS increased. The parameters determined by the Nishi-Wang and Kwei fits were consistent with the interactions between blend components. No difference in the miscibility and interactions between blend components was observed in the blends prepared by physical mixes and co-evaporation. © 2008 Elsevier B.V. All rights reserved.
Subject(s)
Differential scanning calorimetry
Drug interactions
Fourier transform infrared spectroscopy
Glass transition
Heating
Hormones
Melting
Polymer blends
Polymer melts
Rapid solidification
Steelmaking
Thermochemistry
Drug-polymer interaction
FTIR
Melting point depression
MTDSC
Polymethacrylate
Steroid hormone
Melting point
Drug interactions
Fourier transform infrared spectroscopy
Glass transition
Heating
Hormones
Melting
Polymer blends
Polymer melts
Rapid solidification
Steelmaking
Thermochemistry
Drug-polymer interaction
FTIR
Melting point depression
MTDSC
Polymethacrylate
Steroid hormone
Melting point