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Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108

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dc.contributor.authorSawadsitang S.
dc.contributor.authorMongkolthanaruk W.
dc.contributor.authorSuwannasai N.
dc.contributor.authorSodngam S.
dc.date.accessioned2021-04-05T03:25:04Z
dc.date.available2021-04-05T03:25:04Z
dc.date.issued2015
dc.date.issuedBE2558
dc.description.abstractXylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis. The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L (1), fiscalin C (2), epi-fiscalin C (3), cytochalasin D (4), ergosterol (5), ergosterol peroxide (6), chevalone C (7), xylaranol B (8), helvolic acid (9) and cyclo-(l-Pro-l-Leu) (10). The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 values of 3.25 and 5.95 g mL-1. 6 exhibited cytotoxicity against NCI-H187 with an IC50 value of 5.81 g mL-1. 7 and 9 showed antimalarial activity with IC50 values of 25.00 and 6.25 g mL-1, respectively. This result establishes Xylaria as broad spectrum bioactive compound producers. © 2015 Taylor & Francis.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Research. Vol 29, No.21 (2015), p.2033-2036
dc.identifier.doi10.1080/14786419.2015.1017724
dc.identifier.issn14786419
dc.identifier.other2-s2.0-84941599347
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6023
dc.rights.holderScopus
dc.subject.otherAntimalarial agent
dc.subject.otherChevalone c
dc.subject.otherCytochalasin D
dc.subject.otherErgosterol
dc.subject.otherHelvolic acid
dc.subject.otherPlant extract
dc.subject.otherUnclassified drug
dc.subject.otherXylaranol b
dc.subject.otherXylaria cf cubensis extract
dc.subject.otherAntimalarial agent
dc.subject.otherAntineoplastic agent
dc.subject.otherAeromonas hydrophila
dc.subject.otherAntimalarial activity
dc.subject.otherArticle
dc.subject.otherAspergillus fumigatus
dc.subject.otherCancer cell line
dc.subject.otherCephalosporium
dc.subject.otherChromatography
dc.subject.otherCytotoxicity
dc.subject.otherEndophytic fungus
dc.subject.otherFungus
dc.subject.otherIC50
dc.subject.otherMorphological trait
dc.subject.otherNonhuman
dc.subject.otherPseudomonas aeruginosa
dc.subject.otherTrichoderma atroviride
dc.subject.otherVero cell line
dc.subject.otherXylaria cf cubensis
dc.subject.otherAnimal
dc.subject.otherChemical structure
dc.subject.otherChemistry
dc.subject.otherHuman
dc.subject.otherIsolation and purification
dc.subject.otherTumor cell line
dc.subject.otherXylariales
dc.subject.otherAnimals
dc.subject.otherAntimalarials
dc.subject.otherAntineoplastic Agents
dc.subject.otherCell Line, Tumor
dc.subject.otherHumans
dc.subject.otherInhibitory Concentration 50
dc.subject.otherMolecular Structure
dc.subject.otherXylariales
dc.titleAntimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84941599347&doi=10.1080%2f14786419.2015.1017724&partnerID=40&md5=257d3b7095aaa7c7d5031e25afcecd6a

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