Publication:
Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108

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Issued Date

2015

Resource Type

Article

File Type

application/pdf

ISSN

14786419

DOI

10.1080/14786419.2015.1017724

Other identifier(s)

2-s2.0-84941599347

Rights Holder(s)

Scopus

Bibliographic Citation

Natural Product Research. Vol 29, No.21 (2015), p.2033-2036

Suggested Citation

Sawadsitang S., Mongkolthanaruk W., Suwannasai N., Sodngam S. Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108. Natural Product Research. Vol 29, No.21 (2015), p.2033-2036. doi:10.1080/14786419.2015.1017724 Retrieved from: https://hdl.handle.net/20.500.14740/6023

Title

Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108

Author(s)

Sawadsitang S.
 Mongkolthanaruk W.
 Suwannasai N.
 Sodngam S.

Abstract

Xylaria cf. cubensis PK108 was identified by its distinctive morphological characteristics and its internal transcribed spacers sequence analysis. The chromatographic separation and structural elucidation based on spectroscopic analysis of fungal crude extracts led to 10 compounds; tryptoquivaline L (1), fiscalin C (2), epi-fiscalin C (3), cytochalasin D (4), ergosterol (5), ergosterol peroxide (6), chevalone C (7), xylaranol B (8), helvolic acid (9) and cyclo-(l-Pro-l-Leu) (10). The bioassay screening showed that 4 displayed cytotoxicity against KB and NCI-H187 cancer cell lines with IC50 values of 3.25 and 5.95 g mL-1. 6 exhibited cytotoxicity against NCI-H187 with an IC50 value of 5.81 g mL-1. 7 and 9 showed antimalarial activity with IC50 values of 25.00 and 6.25 g mL-1, respectively. This result establishes Xylaria as broad spectrum bioactive compound producers. © 2015 Taylor & Francis.

Subject(s)

Antimalarial agent
 Chevalone c
 Cytochalasin D
 Ergosterol
 Helvolic acid
 Plant extract
 Unclassified drug
 Xylaranol b
 Xylaria cf cubensis extract
 Antimalarial agent
 Antineoplastic agent
 Aeromonas hydrophila
 Antimalarial activity
 Article
 Aspergillus fumigatus
 Cancer cell line
 Cephalosporium
 Chromatography
 Cytotoxicity
 Endophytic fungus
 Fungus
 IC50
 Morphological trait
 Nonhuman
 Pseudomonas aeruginosa
 Trichoderma atroviride
 Vero cell line
 Xylaria cf cubensis
 Animal
 Chemical structure
 Chemistry
 Human
 Isolation and purification
 Tumor cell line
 Xylariales
 Animals
 Antimalarials
 Antineoplastic Agents
 Cell Line, Tumor
 Humans
 Inhibitory Concentration 50
 Molecular Structure
 Xylariales

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URI

https://hdl.handle.net/20.500.14740/6023

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Scopus: Year 1983-2021

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