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Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs

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dc.contributor.authorSudta P.
dc.contributor.authorJiarawapi P.
dc.contributor.authorSuksamrarn A.
dc.contributor.authorHongmanee P.
dc.contributor.authorSuksamrarn S.
dc.date.accessioned2021-04-05T03:33:11Z
dc.date.available2021-04-05T03:33:11Z
dc.date.issued2013
dc.date.issuedBE2556
dc.description.abstractA new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan.
dc.format.mimetypeapplication/pdf
dc.identifier.citationChemical and Pharmaceutical Bulletin. Vol 61, No.2 (2013), p.194-203
dc.identifier.doi10.1248/cpb.c12-00874
dc.identifier.issn92363
dc.identifier.other2-s2.0-84873593744
dc.identifier.urihttps://hdl.handle.net/20.500.14740/6715
dc.rights.holderมหาวิทยาลัยศรีนครินทรวิโรฒ
dc.subject.other3,6 di o (4 bromobutyl)tetrahydro alpha mangostin
dc.subject.other3,6 di o allyltetrahydro alpha mangostin
dc.subject.other3,6 di o benzyltetrahydro alpha mangostin
dc.subject.other3,6 di o ethyl alpha mangostin
dc.subject.other3,6 di o methyl alpha mangostin
dc.subject.other6 methoxytetrahydro alpha mangostin
dc.subject.other6 o (4 bromobutyl)tetrahydro alpha mangostin
dc.subject.other6 o allyltetrahydro alpha mangostin
dc.subject.other6 o benzyltetrahydro alpha mangostin
dc.subject.other6 o butyltetrahydro alpha mangostin
dc.subject.other6 o ethyl alpha mangostin
dc.subject.other6 o methyl alpha mangostin
dc.subject.other6 o methyltetrahydro alpha mangostin
dc.subject.other6 o methyltetrahydro alpha mangostin 3 o acetate
dc.subject.other6 o pentyltetrahydro alpha mangostin
dc.subject.otherAlpha mangostin 3,6 di o acetate
dc.subject.otherAlpha mangostin 3,6 di o benzoate
dc.subject.otherAlpha mangostin 6 o acetate
dc.subject.otherAlpha mangostin 6 o benzoate
dc.subject.otherAlpha mangostin derivative
dc.subject.otherAntimycobacterial agent
dc.subject.otherTetrahydro alpha mangostin
dc.subject.otherTetrahydro alpha mangostin 3,6 di o acetate
dc.subject.otherTetrahydro alpha mangostin 3,6 di o benzoate
dc.subject.otherTetrahydro alpha mangostin 3,6 di o butyrate
dc.subject.otherTetrahydro alpha mangostin 3,6 di o propionate
dc.subject.otherTetrahydro alpha mangostin 6 o acetate
dc.subject.otherTetrahydro alpha mangostin 6 o benzoate
dc.subject.otherTuberculostatic agent
dc.subject.otherUnclassified drug
dc.subject.otherUnindexed drug
dc.subject.otherAcylation
dc.subject.otherAlkylation
dc.subject.otherAntibacterial activity
dc.subject.otherArticle
dc.subject.otherDrug activity
dc.subject.otherDrug structure
dc.subject.otherDrug synthesis
dc.subject.otherMinimum inhibitory concentration
dc.subject.otherMultidrug resistance
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherNonhuman
dc.subject.otherAnti-Bacterial Agents
dc.subject.otherDrug Resistance, Multiple, Bacterial
dc.subject.otherMicrobial Sensitivity Tests
dc.subject.otherMycobacterium tuberculosis
dc.subject.otherXanthones
dc.titlePotent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84873593744&doi=10.1248%2fcpb.c12-00874&partnerID=40&md5=7044536b1db8ec73e49d221fe3bc1dfb

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