Publication: Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
1
0
Issued Date
2013
Resource Type
File Type
application/pdf
ISSN
92363
Other identifier(s)
2-s2.0-84873593744
Rights Holder(s)
มหาวิทยาลัยศรีนครินทรวิโรฒ
Bibliographic Citation
Chemical and Pharmaceutical Bulletin. Vol 61, No.2 (2013), p.194-203
Suggested Citation
Sudta P., Jiarawapi P., Suksamrarn A., Hongmanee P., Suksamrarn S. Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs. Chemical and Pharmaceutical Bulletin. Vol 61, No.2 (2013), p.194-203. doi:10.1248/cpb.c12-00874 Retrieved from: https://hdl.handle.net/20.500.14740/6715
Abstract
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan.
Subject(s)
3,6 di o (4 bromobutyl)tetrahydro alpha mangostin
3,6 di o allyltetrahydro alpha mangostin
3,6 di o benzyltetrahydro alpha mangostin
3,6 di o ethyl alpha mangostin
3,6 di o methyl alpha mangostin
6 methoxytetrahydro alpha mangostin
6 o (4 bromobutyl)tetrahydro alpha mangostin
6 o allyltetrahydro alpha mangostin
6 o benzyltetrahydro alpha mangostin
6 o butyltetrahydro alpha mangostin
6 o ethyl alpha mangostin
6 o methyl alpha mangostin
6 o methyltetrahydro alpha mangostin
6 o methyltetrahydro alpha mangostin 3 o acetate
6 o pentyltetrahydro alpha mangostin
Alpha mangostin 3,6 di o acetate
Alpha mangostin 3,6 di o benzoate
Alpha mangostin 6 o acetate
Alpha mangostin 6 o benzoate
Alpha mangostin derivative
Antimycobacterial agent
Tetrahydro alpha mangostin
Tetrahydro alpha mangostin 3,6 di o acetate
Tetrahydro alpha mangostin 3,6 di o benzoate
Tetrahydro alpha mangostin 3,6 di o butyrate
Tetrahydro alpha mangostin 3,6 di o propionate
Tetrahydro alpha mangostin 6 o acetate
Tetrahydro alpha mangostin 6 o benzoate
Tuberculostatic agent
Unclassified drug
Unindexed drug
Acylation
Alkylation
Antibacterial activity
Article
Drug activity
Drug structure
Drug synthesis
Minimum inhibitory concentration
Multidrug resistance
Mycobacterium tuberculosis
Nonhuman
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Xanthones
3,6 di o allyltetrahydro alpha mangostin
3,6 di o benzyltetrahydro alpha mangostin
3,6 di o ethyl alpha mangostin
3,6 di o methyl alpha mangostin
6 methoxytetrahydro alpha mangostin
6 o (4 bromobutyl)tetrahydro alpha mangostin
6 o allyltetrahydro alpha mangostin
6 o benzyltetrahydro alpha mangostin
6 o butyltetrahydro alpha mangostin
6 o ethyl alpha mangostin
6 o methyl alpha mangostin
6 o methyltetrahydro alpha mangostin
6 o methyltetrahydro alpha mangostin 3 o acetate
6 o pentyltetrahydro alpha mangostin
Alpha mangostin 3,6 di o acetate
Alpha mangostin 3,6 di o benzoate
Alpha mangostin 6 o acetate
Alpha mangostin 6 o benzoate
Alpha mangostin derivative
Antimycobacterial agent
Tetrahydro alpha mangostin
Tetrahydro alpha mangostin 3,6 di o acetate
Tetrahydro alpha mangostin 3,6 di o benzoate
Tetrahydro alpha mangostin 3,6 di o butyrate
Tetrahydro alpha mangostin 3,6 di o propionate
Tetrahydro alpha mangostin 6 o acetate
Tetrahydro alpha mangostin 6 o benzoate
Tuberculostatic agent
Unclassified drug
Unindexed drug
Acylation
Alkylation
Antibacterial activity
Article
Drug activity
Drug structure
Drug synthesis
Minimum inhibitory concentration
Multidrug resistance
Mycobacterium tuberculosis
Nonhuman
Anti-Bacterial Agents
Drug Resistance, Multiple, Bacterial
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Xanthones