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Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa

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dc.contributor.authorWangchuk P.
dc.contributor.authorKeller P.A.
dc.contributor.authorPyne S.G.
dc.contributor.authorSastraruji T.
dc.contributor.authorTaweechotipatr M.
dc.contributor.authorRattanajak R.
dc.contributor.authorTonsomboon A.
dc.contributor.authorKamchonwongpaisan S.
dc.date.accessioned2021-04-05T03:34:19Z
dc.date.available2021-04-05T03:34:19Z
dc.date.issued2012
dc.date.issuedBE2555
dc.description.abstractThe chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF-α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.
dc.format.mimetypeapplication/pdf
dc.identifier.citationNatural Product Communications. Vol 7, No.5 (2012), p.575-580
dc.identifier.doi10.1177/1934578x1200700507
dc.identifier.issn1934578X
dc.identifier.other2-s2.0-84861505544
dc.identifier.urihttps://hdl.handle.net/20.500.14740/7070
dc.rights.holderScopus
dc.subject.other13 oxocryptopine
dc.subject.other13 oxoprotopine
dc.subject.otherAmoxicillin
dc.subject.otherAmphotericin B
dc.subject.otherAntibiotic agent
dc.subject.otherAntiflagellate agent
dc.subject.otherAntifungal agent
dc.subject.otherAntiinflammatory agent
dc.subject.otherAntimalarial agent
dc.subject.otherAntitrypanosomal agent
dc.subject.otherBicuculline
dc.subject.otherChloroquine
dc.subject.otherCoreximine
dc.subject.otherCorydalis crispa extract
dc.subject.otherCycloguanil
dc.subject.otherDexamethasone
dc.subject.otherGalantamine
dc.subject.otherOchrobirine
dc.subject.otherPb 113
dc.subject.otherPlant extract
dc.subject.otherPlant medicinal product
dc.subject.otherProtopine
dc.subject.otherPyrimethamine
dc.subject.otherRheagenine
dc.subject.otherSibiricine
dc.subject.otherStylopine
dc.subject.otherUnclassified drug
dc.subject.otherVancomycin
dc.subject.otherAntibacterial activity
dc.subject.otherAntifungal activity
dc.subject.otherAntiinflammatory activity
dc.subject.otherAntiprotozoal activity
dc.subject.otherArticle
dc.subject.otherBhutan
dc.subject.otherBiological activity
dc.subject.otherControlled study
dc.subject.otherCorydalis crispa
dc.subject.otherCytokine production
dc.subject.otherDrug isolation
dc.subject.otherDrug mechanism
dc.subject.otherDrug screening
dc.subject.otherDrug structure
dc.subject.otherEnzyme inhibition
dc.subject.otherNonhuman
dc.subject.otherNuclear magnetic resonance
dc.subject.otherPapaveraceae
dc.subject.otherPhytochemistry
dc.subject.otherPlasmodium falciparum
dc.subject.otherCorydalis
dc.subject.otherFumariaceae
dc.subject.otherPlasmodium falciparum
dc.titlePhytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa
dc.typeArticle
dspace.entity.typePublication
swu.datasource.scopushttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84861505544&doi=10.1177%2f1934578x1200700507&partnerID=40&md5=32ca02c41f971064f9320f03e533e056

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